Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 51593..52236 Replicon plasmid pXHKP6-1
Accession NZ_CP066888
Organism Klebsiella pneumoniae strain XHKP6

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag JG758_RS27145 Protein ID WP_001044770.1
Coordinates 51593..52009 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag JG758_RS27150 Protein ID WP_001261282.1
Coordinates 52006..52236 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG758_RS27125 (47696) 47696..47968 - 273 Protein_53 transposase -
JG758_RS27135 (48950) 48950..49972 - 1023 WP_000361404.1 helicase UvrD -
JG758_RS27140 (49957) 49957..51519 - 1563 WP_004206609.1 AAA family ATPase -
JG758_RS27145 (51593) 51593..52009 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
JG758_RS27150 (52006) 52006..52236 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JG758_RS27155 (52193) 52193..52654 + 462 WP_014343465.1 hypothetical protein -
JG758_RS27160 (52815) 52815..53759 + 945 WP_011977810.1 hypothetical protein -
JG758_RS27165 (53796) 53796..54188 + 393 WP_011977811.1 hypothetical protein -
JG758_RS27170 (54246) 54246..54767 + 522 WP_013214008.1 hypothetical protein -
JG758_RS27175 (54813) 54813..55016 + 204 WP_011977813.1 hypothetical protein -
JG758_RS27180 (55046) 55046..56050 + 1005 WP_011977814.1 hypothetical protein -
JG758_RS27185 (56234) 56234..57013 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaSHV-12 / blaKPC-2 / catA2 / blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB - 1..180300 180300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T185277 WP_001044770.1 NZ_CP066888:c52009-51593 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T185277 NZ_CP088131:c615658-615194 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT185277 WP_001261282.1 NZ_CP066888:c52236-52006 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT185277 NZ_CP088131:c615993-615658 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References