Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5371247..5371872 Replicon chromosome
Accession NZ_CP066887
Organism Klebsiella pneumoniae strain XHKP6

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JG758_RS26495 Protein ID WP_002882817.1
Coordinates 5371247..5371630 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JG758_RS26500 Protein ID WP_004150355.1
Coordinates 5371630..5371872 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG758_RS26480 5368613..5369515 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JG758_RS26485 5369512..5370147 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JG758_RS26490 5370144..5371073 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JG758_RS26495 5371247..5371630 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JG758_RS26500 5371630..5371872 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
JG758_RS26505 5372077..5372994 + 918 WP_002882812.1 alpha/beta hydrolase -
JG758_RS26510 5373008..5373949 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JG758_RS26515 5373994..5374431 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
JG758_RS26520 5374428..5375288 - 861 WP_002882807.1 virulence factor BrkB family protein -
JG758_RS26525 5375282..5375881 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T185276 WP_002882817.1 NZ_CP066887:c5371630-5371247 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T185276 NZ_CP088131:192162-192269 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT185276 WP_004150355.1 NZ_CP066887:c5371872-5371630 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT185276 NZ_CP088131:c192113-192050 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References