Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4891015..4891531 Replicon chromosome
Accession NZ_CP066887
Organism Klebsiella pneumoniae strain XHKP6

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JG758_RS24190 Protein ID WP_002886902.1
Coordinates 4891015..4891299 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JG758_RS24195 Protein ID WP_002886901.1
Coordinates 4891289..4891531 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG758_RS24165 4886499..4886762 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
JG758_RS24170 4886892..4887065 + 174 WP_002886906.1 hypothetical protein -
JG758_RS24175 4887068..4887811 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JG758_RS24180 4888168..4890306 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JG758_RS24185 4890547..4891011 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JG758_RS24190 4891015..4891299 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG758_RS24195 4891289..4891531 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JG758_RS24200 4891609..4893519 - 1911 WP_004152270.1 PRD domain-containing protein -
JG758_RS24205 4893542..4894696 - 1155 WP_002886900.1 lactonase family protein -
JG758_RS24210 4894762..4895502 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T185274 WP_002886902.1 NZ_CP066887:c4891299-4891015 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T185274 NZ_CP088131:191196-191303 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT185274 WP_002886901.1 NZ_CP066887:c4891531-4891289 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT185274 NZ_CP088131:c191138-191084 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References