Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4174996..4175615 Replicon chromosome
Accession NZ_CP066887
Organism Klebsiella pneumoniae strain XHKP6

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JG758_RS20750 Protein ID WP_002892050.1
Coordinates 4175397..4175615 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JG758_RS20745 Protein ID WP_002892066.1
Coordinates 4174996..4175370 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG758_RS20735 4170148..4171341 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JG758_RS20740 4171364..4174510 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JG758_RS20745 4174996..4175370 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JG758_RS20750 4175397..4175615 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JG758_RS20755 4175774..4176340 + 567 WP_002892030.1 maltose O-acetyltransferase -
JG758_RS20760 4176312..4176452 - 141 WP_004147370.1 hypothetical protein -
JG758_RS20765 4176473..4176943 + 471 WP_002892026.1 YlaC family protein -
JG758_RS20770 4176918..4178369 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JG758_RS20775 4178470..4179168 + 699 WP_002892021.1 GNAT family protein -
JG758_RS20780 4179165..4179305 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JG758_RS20785 4179305..4179568 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185272 WP_002892050.1 NZ_CP066887:4175397-4175615 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185272 NZ_CP088130:26702-27007 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185272 WP_002892066.1 NZ_CP066887:4174996-4175370 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185272 NZ_CP088130:26482-26700 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References