Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 802368..802892 Replicon chromosome
Accession NZ_CP066885
Organism Staphylococcus pseudintermedius strain HSP079

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ27_RS03550 Protein ID WP_014613379.1
Coordinates 802539..802892 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ27_RS03545 Protein ID WP_014613378.1
Coordinates 802368..802538 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ27_RS03520 798254..798727 + 474 WP_014613373.1 PH domain-containing protein -
JGZ27_RS03525 798720..800249 + 1530 WP_200265281.1 PH domain-containing protein -
JGZ27_RS03530 800233..800751 + 519 WP_200265282.1 PH domain-containing protein -
JGZ27_RS03535 800748..801074 + 327 WP_200265283.1 holo-ACP synthase -
JGZ27_RS03540 801132..802283 + 1152 WP_200265284.1 alanine racemase -
JGZ27_RS03545 802368..802538 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ27_RS03550 802539..802892 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ27_RS03555 802950..803957 + 1008 WP_200265285.1 PP2C family protein-serine/threonine phosphatase -
JGZ27_RS03560 804036..804362 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ27_RS03565 804362..804793 + 432 Protein_702 anti-sigma B factor RsbW -
JGZ27_RS03570 804818..805588 + 771 WP_200265535.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T185258 WP_014613379.1 NZ_CP066885:802539-802892 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T185258 NZ_CP088126:353135-353482 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT185258 WP_014613378.1 NZ_CP066885:802368-802538 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT185258 NZ_CP088126:353482-353781 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References