185257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 787423..787944 Replicon chromosome
Accession NZ_CP066885
Organism Staphylococcus pseudintermedius strain HSP079

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ27_RS03475 Protein ID WP_014613364.1
Coordinates 787723..787944 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ27_RS03470 Protein ID WP_014613363.1
Coordinates 787423..787710 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ27_RS03445 782676..783482 + 807 WP_200265271.1 hydroxyethylthiazole kinase -
JGZ27_RS03450 783472..784110 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ27_RS03455 784199..785068 + 870 WP_200265272.1 membrane protein insertase YidC -
JGZ27_RS03460 785122..785778 - 657 WP_200265273.1 HD domain-containing protein -
JGZ27_RS03465 785799..787268 - 1470 WP_200265534.1 cardiolipin synthase -
JGZ27_RS03470 787423..787710 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ27_RS03475 787723..787944 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ27_RS03480 787948..788157 + 210 WP_200265274.1 cation transporter -
JGZ27_RS03485 788258..790447 + 2190 WP_200265275.1 heavy metal translocating P-type ATPase -
JGZ27_RS03490 790533..790679 + 147 WP_014613367.1 hypothetical protein -
JGZ27_RS03495 791649..792383 + 735 WP_200265276.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T185257 WP_014613364.1 NZ_CP066885:787723-787944 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T185257 NZ_CP088126:327164-327532 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT185257 WP_014613363.1 NZ_CP066885:787423-787710 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT185257 NZ_CP088126:326946-327167 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References