Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 787323..787844 Replicon chromosome
Accession NZ_CP066884
Organism Staphylococcus pseudintermedius strain HSP080

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ15_RS03470 Protein ID WP_014613364.1
Coordinates 787623..787844 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ15_RS03465 Protein ID WP_014613363.1
Coordinates 787323..787610 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ15_RS03440 782579..783385 + 807 WP_200265271.1 hydroxyethylthiazole kinase -
JGZ15_RS03445 783375..784013 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ15_RS03450 784102..784968 + 867 WP_200361174.1 membrane protein insertase YidC -
JGZ15_RS03455 785022..785678 - 657 WP_200265273.1 HD domain-containing protein -
JGZ15_RS03460 785699..787168 - 1470 WP_200361415.1 cardiolipin synthase -
JGZ15_RS03465 787323..787610 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ15_RS03470 787623..787844 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ15_RS03475 787848..788057 + 210 WP_200361176.1 cation transporter -
JGZ15_RS03480 788158..790347 + 2190 WP_200265275.1 heavy metal translocating P-type ATPase -
JGZ15_RS03485 790433..790579 + 147 WP_014613367.1 hypothetical protein -
JGZ15_RS03490 791549..792283 + 735 WP_200361178.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T185254 WP_014613364.1 NZ_CP066884:787623-787844 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T185254 NZ_CP088124:31342-31758 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT185254 WP_014613363.1 NZ_CP066884:787323-787610 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT185254 NZ_CP088124:31115-31345 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References