Detailed information of TA system TA185252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 4885187..4885686
• Replicon: chromosome
• Accession: NZ_CP066853
• Organism: Rhodococcus biphenylivorans strain B403

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JGU70_RS22540
• Protein ID: WP_019290516.1
• Coordinates: 4885187..4885441 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JGU70_RS22545
• Protein ID: WP_019290515.1
• Coordinates: 4885438..4885686 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGU70_RS22515	4880621..4881790	-	1170	WP_006550848.1	acyl-CoA dehydrogenase family protein	-
JGU70_RS22520	4881893..4882519	+	627	WP_006550849.1	TetR family transcriptional regulator	-
JGU70_RS22525	4883007..4883138	-	132	WP_200360277.1	transposase	-
JGU70_RS22530	4883452..4884408	-	957	WP_019290518.1	Lsr2 family protein	-
JGU70_RS22535	4884565..4885086	+	522	WP_200359089.1	hypothetical protein	-
JGU70_RS22540	4885187..4885441	-	255	WP_019290516.1	Txe/YoeB family addiction module toxin	Toxin
JGU70_RS22545	4885438..4885686	-	249	WP_019290515.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JGU70_RS22550	4885760..4886050	+	291	WP_200360278.1	hypothetical protein	-
JGU70_RS22555	4886517..4887311	+	795	WP_006550857.1	LLM class F420-dependent oxidoreductase	-
JGU70_RS22560	4887372..4888604	+	1233	WP_064852696.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10078.37 Da
• Isoelectric Point: 6.7171

>T185252 WP_019290516.1 NZ_CP066853:c4885441-4885187 [Rhodococcus biphenylivorans]
VNITFTDEAWDDYQFWISTDRKQLERVNELIRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Nucleotide

• Length: 255 bp

>T185252 NZ_CP088124:c20816-20511 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9264.55 Da
• Isoelectric Point: 6.4661

>AT185252 WP_019290515.1 NZ_CP066853:c4885686-4885438 [Rhodococcus biphenylivorans]
MAAITATEARKNFFPLLEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEHTEREL
IE

Nucleotide

• Length: 249 bp

>AT185252 NZ_CP088124:c21036-20818 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA