Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 654348..654913 Replicon chromosome
Accession NZ_CP066853
Organism Rhodococcus biphenylivorans strain B403

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JGU70_RS03125 Protein ID WP_024102981.1
Coordinates 654635..654913 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JGU70_RS03120 Protein ID WP_006551856.1
Coordinates 654348..654638 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGU70_RS03095 649581..650183 + 603 WP_019290064.1 TetR/AcrR family transcriptional regulator -
JGU70_RS03100 650180..650608 + 429 WP_039585870.1 HIT family protein -
JGU70_RS03105 650613..652214 + 1602 WP_039585873.1 L-lactate permease -
JGU70_RS03110 652291..653319 + 1029 WP_200359400.1 Dyp-type peroxidase -
JGU70_RS03115 653316..654134 + 819 WP_006551857.1 bacteriocin family protein -
JGU70_RS03120 654348..654638 + 291 WP_006551856.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JGU70_RS03125 654635..654913 + 279 WP_024102981.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JGU70_RS03130 654970..655449 - 480 WP_006551854.1 MarR family transcriptional regulator -
JGU70_RS03135 655508..656257 - 750 WP_024102983.1 cutinase family protein -
JGU70_RS03140 656407..657069 - 663 WP_024102984.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
JGU70_RS03145 657190..658020 + 831 WP_006551851.1 SDR family oxidoreductase -
JGU70_RS03150 658065..659036 + 972 WP_006551850.1 phosphotriesterase -
JGU70_RS03155 659073..659792 - 720 WP_033096970.1 2OG-Fe(II) oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(34-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10268.82 Da        Isoelectric Point: 10.2002

>T185250 WP_024102981.1 NZ_CP066853:654635-654913 [Rhodococcus biphenylivorans]
MSTPDHPYRLVMARSAARAMARSLPEKVATAVYEFVTGPLLENPKRVGKPLNPPLAPAYSARRGEYRVLYLIDDANRTVE
VTAISHRADAYR

Download         Length: 279 bp

>T185250 NZ_CP088121:195250-195534 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10788.92 Da        Isoelectric Point: 4.2336

>AT185250 WP_006551856.1 NZ_CP066853:654348-654638 [Rhodococcus biphenylivorans]
MYMTTLPVADARAQLSRLVDEAERTHERFEITRNGHRAAVLLGADDYDAMQETIAVLSDTDLLRAHVEGRTEVESGDVVD
VQELTQLMRDARSSEE

Download         Length: 291 bp

>AT185250 NZ_CP088121:195012-195260 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References