Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 2539521..2540043 | Replicon | chromosome |
Accession | NZ_CP066851 | ||
Organism | Salmonella enterica subsp. enterica serovar Heidelberg strain SH-2813-Parental |
Toxin (Protein)
Gene name | stbE | Uniprot ID | A0A5V5H0Y9 |
Locus tag | JIG31_RS12330 | Protein ID | WP_000221348.1 |
Coordinates | 2539521..2539805 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | V1H457 |
Locus tag | JIG31_RS12335 | Protein ID | WP_000885424.1 |
Coordinates | 2539795..2540043 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JIG31_RS12310 (2535597) | 2535597..2537105 | - | 1509 | WP_000214838.1 | FAD-dependent oxidoreductase | - |
JIG31_RS12315 (2537150) | 2537150..2537638 | + | 489 | WP_001293629.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
JIG31_RS12320 (2537830) | 2537830..2538903 | + | 1074 | WP_000954686.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
JIG31_RS12325 (2538961) | 2538961..2539350 | - | 390 | WP_001531585.1 | RidA family protein | - |
JIG31_RS12330 (2539521) | 2539521..2539805 | - | 285 | WP_000221348.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JIG31_RS12335 (2539795) | 2539795..2540043 | - | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
JIG31_RS12340 (2540195) | 2540195..2540410 | + | 216 | WP_000206207.1 | hypothetical protein | - |
JIG31_RS12345 (2540400) | 2540400..2540732 | + | 333 | WP_000253097.1 | DUF1493 family protein | - |
JIG31_RS12350 (2540883) | 2540883..2541790 | + | 908 | Protein_2429 | hypothetical protein | - |
JIG31_RS12355 (2541846) | 2541846..2542614 | - | 769 | Protein_2430 | helix-turn-helix domain-containing protein | - |
JIG31_RS12360 (2543425) | 2543425..2544333 | + | 909 | WP_001176641.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11093.88 Da Isoelectric Point: 10.6500
>T185237 WP_000221348.1 NZ_CP066851:c2539805-2539521 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYKLAFNESALKEWKKMGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
MTYKLAFNESALKEWKKMGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
Download Length: 285 bp
>T185237 NZ_CP088119:c3920089-3919679 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT185237 WP_000885424.1 NZ_CP066851:c2540043-2539795 [Salmonella enterica subsp. enterica serovar Heidelberg]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT185237 NZ_CP088119:c3920336-3920070 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5V5H0Y9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0WPN5 |