Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2539521..2540043 Replicon chromosome
Accession NZ_CP066851
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain SH-2813-Parental

Toxin (Protein)


Gene name stbE Uniprot ID A0A5V5H0Y9
Locus tag JIG31_RS12330 Protein ID WP_000221348.1
Coordinates 2539521..2539805 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag JIG31_RS12335 Protein ID WP_000885424.1
Coordinates 2539795..2540043 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIG31_RS12310 (2535597) 2535597..2537105 - 1509 WP_000214838.1 FAD-dependent oxidoreductase -
JIG31_RS12315 (2537150) 2537150..2537638 + 489 WP_001293629.1 MarR family winged helix-turn-helix transcriptional regulator -
JIG31_RS12320 (2537830) 2537830..2538903 + 1074 WP_000954686.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
JIG31_RS12325 (2538961) 2538961..2539350 - 390 WP_001531585.1 RidA family protein -
JIG31_RS12330 (2539521) 2539521..2539805 - 285 WP_000221348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JIG31_RS12335 (2539795) 2539795..2540043 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JIG31_RS12340 (2540195) 2540195..2540410 + 216 WP_000206207.1 hypothetical protein -
JIG31_RS12345 (2540400) 2540400..2540732 + 333 WP_000253097.1 DUF1493 family protein -
JIG31_RS12350 (2540883) 2540883..2541790 + 908 Protein_2429 hypothetical protein -
JIG31_RS12355 (2541846) 2541846..2542614 - 769 Protein_2430 helix-turn-helix domain-containing protein -
JIG31_RS12360 (2543425) 2543425..2544333 + 909 WP_001176641.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11093.88 Da        Isoelectric Point: 10.6500

>T185237 WP_000221348.1 NZ_CP066851:c2539805-2539521 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYKLAFNESALKEWKKMGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T185237 NZ_CP088119:c3920089-3919679 [Enterobacter kobei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTGTTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT185237 WP_000885424.1 NZ_CP066851:c2540043-2539795 [Salmonella enterica subsp. enterica serovar Heidelberg]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT185237 NZ_CP088119:c3920336-3920070 [Enterobacter kobei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V5H0Y9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References