185236

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1486289..1486909 Replicon chromosome
Accession NZ_CP066851
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain SH-2813-Parental

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JIG31_RS07045 Protein ID WP_001280991.1
Coordinates 1486289..1486507 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JIG31_RS07050 Protein ID WP_000344807.1
Coordinates 1486535..1486909 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIG31_RS07005 (1481513) 1481513..1482082 + 570 WP_000779803.1 YbaY family lipoprotein -
JIG31_RS07010 (1482115) 1482115..1482504 - 390 WP_000961285.1 MGMT family protein -
JIG31_RS07020 (1482735) 1482735..1484285 - 1551 WP_000213139.1 EAL domain-containing protein -
JIG31_RS07025 (1484510) 1484510..1484770 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
JIG31_RS07030 (1484776) 1484776..1484916 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JIG31_RS07035 (1484972) 1484972..1485442 - 471 WP_000136181.1 YlaC family protein -
JIG31_RS07040 (1485559) 1485559..1486110 - 552 WP_001278792.1 maltose O-acetyltransferase -
JIG31_RS07045 (1486289) 1486289..1486507 - 219 WP_001280991.1 HHA domain-containing protein Toxin
JIG31_RS07050 (1486535) 1486535..1486909 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JIG31_RS07055 (1487405) 1487405..1490554 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
JIG31_RS07060 (1490577) 1490577..1491770 - 1194 WP_031613309.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T185236 WP_001280991.1 NZ_CP066851:c1486507-1486289 [Salmonella enterica subsp. enterica serovar Heidelberg]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T185236 NZ_CP088119:c2915477-2915374 [Enterobacter kobei]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT185236 WP_000344807.1 NZ_CP066851:c1486909-1486535 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT185236 NZ_CP088119:2915358-2915512 [Enterobacter kobei]
TGTCTTTCATACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTG
CGCTAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References