185231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 745944..746460 Replicon chromosome
Accession NZ_CP066851
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain SH-2813-Parental

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag JIG31_RS03525 Protein ID WP_000220577.1
Coordinates 746176..746460 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag JIG31_RS03520 Protein ID WP_000212724.1
Coordinates 745944..746186 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIG31_RS03500 (740964) 740964..742097 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
JIG31_RS03505 (742081) 742081..743199 + 1119 WP_001139173.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
JIG31_RS03510 (743196) 743196..743936 + 741 WP_000779250.1 KDGP aldolase family protein -
JIG31_RS03515 (743953) 743953..745866 + 1914 WP_001212135.1 BglG family transcription antiterminator -
JIG31_RS03520 (745944) 745944..746186 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JIG31_RS03525 (746176) 746176..746460 + 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JIG31_RS03530 (746464) 746464..746928 - 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JIG31_RS03535 (747145) 747145..749283 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
JIG31_RS03540 (749692) 749692..751344 - 1653 WP_000155047.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T185231 WP_000220577.1 NZ_CP066851:746176-746460 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T185231 NZ_CP088119:c1007003-1006662 [Enterobacter kobei]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT185231 WP_000212724.1 NZ_CP066851:745944-746186 [Salmonella enterica subsp. enterica serovar Heidelberg]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT185231 NZ_CP088119:c1007341-1007024 [Enterobacter kobei]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References