Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206448..207208 Replicon chromosome
Accession NZ_CP066851
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain SH-2813-Parental

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag JIG31_RS00975 Protein ID WP_000533909.1
Coordinates 206723..207208 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag JIG31_RS00970 Protein ID WP_000965886.1
Coordinates 206448..206735 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIG31_RS00945 (201743) 201743..202045 + 303 WP_000605590.1 YsaB family lipoprotein -
JIG31_RS00950 (202184) 202184..203095 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
JIG31_RS00955 (203105) 203105..205174 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
JIG31_RS00960 (205356) 205356..205631 + 276 Protein_190 IS3 family transposase -
JIG31_RS00965 (205803) 205803..206270 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
JIG31_RS00970 (206448) 206448..206735 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
JIG31_RS00975 (206723) 206723..207208 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
JIG31_RS00980 (207580) 207580..208119 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
JIG31_RS00985 (208293) 208293..208505 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JIG31_RS00990 (208794) 208794..209084 - 291 WP_000455790.1 HTH-type transcriptional regulator -
JIG31_RS00995 (209522) 209522..210232 + 711 WP_219656216.1 DUF3053 domain-containing protein -
JIG31_RS01000 (210282) 210282..211256 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
JIG31_RS01005 (211475) 211475..212137 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T185229 WP_000533909.1 NZ_CP066851:206723-207208 [Salmonella enterica subsp. enterica serovar Heidelberg]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T185229 NZ_CP088119:497463-497813 [Enterobacter kobei]
ATGGTGAAGCGACCTTGTTTTGAACGAGGTGATATCGTTCTCGTCGGCTTCGATCCTGCAAATGGTCATGAACAAAAGGG
CGCAGGCAGGCCCGCTTTAGTGCTATCCGTTAGCGCGTTCAACCAGCTGGGAATGACGCTGGTTGCGCCTGTTACACAGG
GAGGAAATTTTGCCCGCTATGCGGGTTTCAGTGTGCCGCTGTCTTGTGAAGAAGGGAATATTCAGGGCGTCATTCTGGTA
AACCAAATCCGAATGATGGATTTGGGCGCGCGTCTGGCAAAACGAATAGGCGTGGCATCAGATGAAACCGTAGAAGATGC
GCTTTTAAGGCTACAGGCCATCCTGAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT185229 WP_000965886.1 NZ_CP066851:206448-206735 [Salmonella enterica subsp. enterica serovar Heidelberg]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT185229 NZ_CP088119:497218-497469 [Enterobacter kobei]
ATGCGTATAACCATTAAGAAATGGGGAAACAGTGCCGGTATGGTCATTCCTGGCGTAGTAATGAAAGAACTTGGCCTAAA
ACCAGGTCAGAGTATGGAGGCTCAGGTGACAAATAATCAGTTAGTGCTCACACCGGTGAGTAAACAGTACTCGCTTGAAG
AGTTGTTGGCGCAGTGTGATATGTCAGCCCCGGAAATTAACGAACAAGACGTATGGGGTACGTCAGGTCCCGTAGGTGAC
GAAGTATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References