Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 942178..942832 Replicon chromosome
Accession NZ_CP066844
Organism Escherichia coli strain Z30

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag JHL13_RS04520 Protein ID WP_000244765.1
Coordinates 942425..942832 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JHL13_RS04515 Protein ID WP_000354046.1
Coordinates 942178..942444 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHL13_RS04495 (938266) 938266..939699 - 1434 WP_063082439.1 6-phospho-beta-glucosidase BglA -
JHL13_RS04500 (939744) 939744..940055 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
JHL13_RS04505 (940219) 940219..940878 + 660 WP_000250274.1 hemolysin III family protein -
JHL13_RS04510 (940955) 940955..941935 - 981 WP_049038218.1 tRNA-modifying protein YgfZ -
JHL13_RS04515 (942178) 942178..942444 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JHL13_RS04520 (942425) 942425..942832 + 408 WP_000244765.1 protein YgfX Toxin
JHL13_RS04525 (942872) 942872..943393 - 522 WP_001055874.1 flavodoxin FldB -
JHL13_RS04530 (943505) 943505..944401 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JHL13_RS04535 (944426) 944426..945136 + 711 WP_088845923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JHL13_RS04540 (945142) 945142..946875 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T185200 WP_000244765.1 NZ_CP066844:942425-942832 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T185200 NZ_CP088104:275398-275643 [Rhizobium ruizarguesonis]
ATGAAAAAGATCGCCTACAGCAAGGCTGCCGCGAAGGCACTCCGCAAGATGCAGCCGAAGCGCGCAGCGGCGATCGTCGC
CAAGGTCGAAGCCTTCGCCAACGGCGAGACGGTCGACCTCAAGAAGCTGCAAGGCAGCGATTTTTTTCGAATTCGTGTCG
GGCAGGACCGCGTCGTCATCGACGATCAGACCATGCAGGTCCTCGTCATCAAGGCCGGCCCACGCGGCGACATCTATAAC
GAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT185200 WP_000354046.1 NZ_CP066844:942178-942444 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185200 NZ_CP088104:275653-276000 [Rhizobium ruizarguesonis]
ATGGGTGAAATCCAGAAACTGACCATCGACGGCAAGGGGTACGTGCTGCTTTCCGAAGACGACTATCAGGACCTTGTCGA
CGTCAGCGACGCGCGTGCCGCAAAGGCGCGTATCGACGCTGGCGAAGAGACCTGGCCTGAAGACGTCGTCAAGGCGCTGA
TCGCCGGCGAAGATCCTGTCCGGGTGTTCCGTAAGCATCGCGGCATGAGTATCAAGGAGTTGGCTAAAAAGTCCGGGCTC
TCCCAGCCCTACCTTTCCGAAATCGAGACCGGAAAGAAGGAGGGCTCCCTGGACGCACTCAGGTCGATCGCCAGCGCGCT
GGACGTCGACCTTGACGATGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References