Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 846045..846880 Replicon chromosome
Accession NZ_CP066844
Organism Escherichia coli strain Z30

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1C0Y405
Locus tag JHL13_RS04005 Protein ID WP_001774607.1
Coordinates 846045..846422 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag JHL13_RS04010 Protein ID WP_001774606.1
Coordinates 846512..846880 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHL13_RS03980 (842118) 842118..843101 - 984 WP_032152721.1 KpsF/GutQ family sugar-phosphate isomerase -
JHL13_RS03985 (843912) 843912..844082 - 171 Protein_782 IS110 family transposase -
JHL13_RS03990 (844424) 844424..845266 - 843 WP_032152755.1 DUF4942 domain-containing protein -
JHL13_RS03995 (845351) 845351..845548 - 198 WP_032152719.1 DUF957 domain-containing protein -
JHL13_RS04000 (845560) 845560..846048 - 489 WP_001774608.1 DUF5983 family protein -
JHL13_RS04005 (846045) 846045..846422 - 378 WP_001774607.1 TA system toxin CbtA family protein Toxin
JHL13_RS04010 (846512) 846512..846880 - 369 WP_001774606.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JHL13_RS04015 (846930) 846930..847574 - 645 WP_001774605.1 hypothetical protein -
JHL13_RS04020 (847593) 847593..847814 - 222 WP_000692312.1 DUF987 domain-containing protein -
JHL13_RS04025 (847877) 847877..848353 - 477 WP_001297237.1 RadC family protein -
JHL13_RS04030 (848369) 848369..848848 - 480 WP_032152717.1 antirestriction protein -
JHL13_RS04035 (849187) 849187..850005 - 819 WP_016238867.1 DUF932 domain-containing protein -
JHL13_RS04040 (850104) 850104..850337 - 234 WP_001278287.1 DUF905 family protein -
JHL13_RS04045 (850343) 850343..851020 - 678 WP_001097305.1 hypothetical protein -
JHL13_RS04050 (851168) 851168..851848 - 681 WP_032082725.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14218.20 Da        Isoelectric Point: 7.8045

>T185199 WP_001774607.1 NZ_CP066844:c846422-846045 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T185199 NZ_CP088103:c6123-5737 [Bradyrhizobium japonicum]
ATGGTGATCGATACGTCCGTCATTGTTGCGATTGCCTTCAATGAGCCTGAGGCAACGAGTTTCCGCGAACGCATTGCCGA
AGATTCCGTTCGTCTCATCTCGGCTGCGACCGTGTTCGAGGCTACCATAGTCATTGAAACGCGCCTGGGTGAAGCGGGCG
GCGCGGAGCTCGATCTGTGGCTACACAAGGCCGATGTTGAGGTGGTCGCCGTCACCGCCGGCCATGCCGACCAGGCCCGC
CGTGCCTGGCGTCGTTACGGCAAAGGGCGCCATCCCGCCGGCCTGAACTTCGGCGATTGTTTTTCCTATGCGCTCGCCGC
CCTCAGCGGCGAACCACTGCTCTTCAAGGGCAATGACTTCGTGCAAACCGAGATTCAGGCCGCATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT185199 WP_001774606.1 NZ_CP066844:c846880-846512 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT185199 NZ_CP088103:c6377-6123 [Bradyrhizobium japonicum]
ATGGCGCTGAGCATCAAGGACCGCGAAACTGAGCAACTCGCCCGCACGCTTGCAGCGCGCACCGGCGAATCGATTACCGT
TGCGACGCGGCGAGCCCTCGAGGAGCGCCTGCGGCGAACCGGTTCCCAGGCCCGCAAGGCGGCTCTTCTGGAGGATTTGG
AAGCAATTCAGCGCCGCTGGAACGCTTTGCCGATTCTCGACAACCGCGCCCCTGACGAGATCGTCGGCTACGACGAGAAC
GGCATCCCAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y405

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References