185162

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4144494..4145328 Replicon chromosome
Accession NZ_CP066836
Organism Escherichia coli strain Ec-FL1-1X

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3TJB4
Locus tag JH476_RS19880 Protein ID WP_000854811.1
Coordinates 4144494..4144871 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag JH476_RS19885 Protein ID WP_001285590.1
Coordinates 4144960..4145328 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH476_RS19860 (4142292) 4142292..4143512 + 1221 WP_000794251.1 capsular biosynthesis protein -
JH476_RS19865 (4143538) 4143538..4143768 - 231 Protein_3899 hypothetical protein -
JH476_RS19870 (4143874) 4143874..4144050 - 177 WP_000839288.1 DUF957 domain-containing protein -
JH476_RS19875 (4144067) 4144067..4144497 - 431 Protein_3901 DUF5983 family protein -
JH476_RS19880 (4144494) 4144494..4144871 - 378 WP_000854811.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
JH476_RS19885 (4144960) 4144960..4145328 - 369 WP_001285590.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JH476_RS19890 (4145402) 4145402..4145623 - 222 WP_000692300.1 DUF987 domain-containing protein -
JH476_RS19895 (4145692) 4145692..4146168 - 477 WP_219648332.1 RadC family protein -
JH476_RS19900 (4146184) 4146184..4146669 - 486 WP_000214310.1 antirestriction protein -
JH476_RS19905 (4146761) 4146761..4147579 - 819 WP_001234593.1 DUF932 domain-containing protein -
JH476_RS19910 (4147697) 4147697..4147868 - 172 Protein_3908 DUF905 family protein -
JH476_RS19915 (4147969) 4147969..4148424 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14041.14 Da        Isoelectric Point: 7.8839

>T185162 WP_000854811.1 NZ_CP066836:c4144871-4144494 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

>T185162 NZ_CP088019:4745022-4745309 [Pectobacterium carotovorum]
ATGAGTTATCGCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGCTCAAGCTCGATAAAACCATTCAGCAGCAATTTGC
CAAAAAACTAAAAGAATGCTGCGAAAATCCCCATATTCCTGCGGCAAAGTTACGAGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCATCAGGCTTTCGTTTGGTTTACGAGGTTATTGACGACGTATTGATTATCGCCGTGGTGGCGGTAGGCAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT185162 WP_001285590.1 NZ_CP066836:c4145328-4144960 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT185162 NZ_CP088019:4744774-4745025 [Pectobacterium carotovorum]
ATGCCGAATATTATATTAAGCGATACCAGTGCTAGCGTCAGTGAACTGAAAAAGAACCCGATGGCAACGGTCAATGCTGG
TGATGGCCTGCCTGTTGCTATCTTAAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGATTAAGCTGATCGGTGAACGTAAAAACCAGCCGCTGGTTGACGTAGATTTGGAT
AGTTTCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3TJB4

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References