185156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2822761..2823596 Replicon chromosome
Accession NZ_CP066836
Organism Escherichia coli strain Ec-FL1-1X

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1C0Y405
Locus tag JH476_RS13680 Protein ID WP_001774607.1
Coordinates 2823219..2823596 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag JH476_RS13675 Protein ID WP_001774606.1
Coordinates 2822761..2823129 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JH476_RS13635 (2817793) 2817793..2818473 + 681 WP_219648325.1 WYL domain-containing protein -
JH476_RS13640 (2818621) 2818621..2819298 + 678 WP_001097305.1 hypothetical protein -
JH476_RS13645 (2819304) 2819304..2819537 + 234 WP_001278287.1 DUF905 family protein -
JH476_RS13650 (2819636) 2819636..2820454 + 819 WP_016238867.1 DUF932 domain-containing protein -
JH476_RS13655 (2820793) 2820793..2821272 + 480 WP_032152717.1 antirestriction protein -
JH476_RS13660 (2821288) 2821288..2821764 + 477 WP_001297237.1 RadC family protein -
JH476_RS13665 (2821827) 2821827..2822048 + 222 WP_000692312.1 DUF987 domain-containing protein -
JH476_RS13670 (2822067) 2822067..2822711 + 645 WP_001774605.1 hypothetical protein -
JH476_RS13675 (2822761) 2822761..2823129 + 369 WP_001774606.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JH476_RS13680 (2823219) 2823219..2823596 + 378 WP_001774607.1 TA system toxin CbtA family protein Toxin
JH476_RS13685 (2823593) 2823593..2824081 + 489 WP_001774608.1 DUF5983 family protein -
JH476_RS13690 (2824093) 2824093..2824290 + 198 WP_032152719.1 DUF957 domain-containing protein -
JH476_RS13695 (2824375) 2824375..2825217 + 843 WP_032152755.1 DUF4942 domain-containing protein -
JH476_RS13700 (2825966) 2825966..2827504 + 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(B) / sul2 papB / papI 2781593..2835316 53723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14218.20 Da        Isoelectric Point: 7.8045

>T185156 WP_001774607.1 NZ_CP066836:2823219-2823596 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T185156 NZ_CP088019:c1313746-1313543 [Pectobacterium carotovorum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCTGAACTGACAATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT185156 WP_001774606.1 NZ_CP066836:2822761-2823129 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT185156 NZ_CP088019:c1314168-1313800 [Pectobacterium carotovorum]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGTTCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGCATTAATGATGCTGAACTACGGCGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y405

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References