Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4065096..4066667 Replicon chromosome
Accession NZ_CP066833
Organism Proteus mirabilis strain RGF134-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JEQ15_RS18870 Protein ID WP_063073818.1
Coordinates 4065096..4066409 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JEQ15_RS18875 Protein ID WP_049203075.1
Coordinates 4066410..4066667 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JEQ15_RS18850 (JEQ15_18805) 4060265..4061068 + 804 WP_063073815.1 energy transducer TonB -
JEQ15_RS18855 (JEQ15_18810) 4061122..4063083 - 1962 WP_063073816.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
JEQ15_RS18860 (JEQ15_18815) 4063115..4064044 - 930 WP_004246518.1 metallophosphoesterase -
JEQ15_RS18865 (JEQ15_18820) 4064229..4064693 - 465 WP_063073817.1 DUF1097 domain-containing protein -
JEQ15_RS18870 (JEQ15_18825) 4065096..4066409 - 1314 WP_063073818.1 type II toxin-antitoxin system HipA family toxin Toxin
JEQ15_RS18875 (JEQ15_18830) 4066410..4066667 - 258 WP_049203075.1 helix-turn-helix domain-containing protein Antitoxin
JEQ15_RS18880 (JEQ15_18835) 4066943..4067572 - 630 WP_001145449.1 hypothetical protein -
JEQ15_RS18885 (JEQ15_18840) 4067920..4068684 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
JEQ15_RS18890 (JEQ15_18845) 4069006..4070931 + 1926 WP_000766277.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49674.86 Da        Isoelectric Point: 6.7643

>T185136 WP_063073818.1 NZ_CP066833:c4066409-4065096 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLVAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKKYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

>T185136 NZ_CP088009:526768-527178 [Rhizobium sp. T136]
GTGCTAAAGTACATGCTCGACACGAACATCTGCATTTTCACCGTGAAGAGTCGTCCGCCGCAGGTCCGCGAAGCATTCAA
CCGCCACCATGGTCAACTGTGCATCAGCTCAGTCACCTTGATGGAGCTGGTCTACGGTGCGGAAAAGTCGGCCAATCCAG
AACGAAACCTCTCCGTAGTCGAGGGCTTTGCCGCACGGCTTGAGGTGCTTGCCTACGATCAAATGGCAGCGAGCCATACG
GGCCAATTGCGTGCCGAGCTCGCGCGCGGCGGAACTCCGATCGGACCATACGACCAGCTGATTGCCGGTCACGCCCGCTC
GAGGGGGCTGATATTGGTCACAAACAACCGACGTGAGTTCGATCGAGTACCTGGCCTACGCGTCGAAGACTGGACAGTTT
CGGCGCCTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT185136 WP_049203075.1 NZ_CP066833:c4066667-4066410 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT185136 NZ_CP088009:526538-526768 [Rhizobium sp. T136]
ATGGAGCAAGGAGCCGTGTTTCAGAGCAATCGTAGCCAAGCCGTTCGACTACCGAAGGCCGTCGCGCTTCCCGAGGATGT
AAAGCGGGTTGATATCGTTGCAGTCGGGCGCACGAGGATTATAGCACCCGCGGGTGAAGTCTGGGACAGCTGGTTCGATG
GTGAAGGTGCGACGTCCGACTTCATGAACGAACGCGATCAGCCGACCTTGCAGGAGCGCGAGGCGTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References