Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3812839..3813640 Replicon chromosome
Accession NZ_CP066833
Organism Proteus mirabilis strain RGF134-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag JEQ15_RS17635 Protein ID WP_001094437.1
Coordinates 3812839..3813216 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag JEQ15_RS17640 Protein ID WP_001390338.1
Coordinates 3813263..3813640 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JEQ15_RS17605 (JEQ15_17565) 3808261..3808581 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
JEQ15_RS17610 (JEQ15_17570) 3809352..3809504 + 153 Protein_3413 integrase core domain-containing protein -
JEQ15_RS17615 (JEQ15_17575) 3809629..3810663 - 1035 WP_017628609.1 RhuM family protein -
JEQ15_RS17620 (JEQ15_17580) 3811207..3812052 - 846 WP_001274561.1 DUF4942 domain-containing protein -
JEQ15_RS17625 (JEQ15_17585) 3812137..3812334 - 198 WP_000772032.1 DUF957 domain-containing protein -
JEQ15_RS17630 (JEQ15_17590) 3812354..3812842 - 489 WP_000761716.1 DUF5983 family protein -
JEQ15_RS17635 (JEQ15_17595) 3812839..3813216 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
JEQ15_RS17640 (JEQ15_17600) 3813263..3813640 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JEQ15_RS17645 (JEQ15_17605) 3813803..3814024 - 222 WP_000692345.1 DUF987 domain-containing protein -
JEQ15_RS17650 (JEQ15_17610) 3814087..3814563 - 477 WP_001535682.1 RadC family protein -
JEQ15_RS17655 (JEQ15_17615) 3814579..3815052 - 474 WP_000855064.1 antirestriction protein -
JEQ15_RS17660 (JEQ15_17620) 3815394..3816212 - 819 WP_001535681.1 DUF932 domain-containing protein -
JEQ15_RS17665 (JEQ15_17625) 3816330..3816525 - 196 Protein_3424 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T185135 WP_001094437.1 NZ_CP066833:c3813216-3812839 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T185135 NZ_CP088008:5286406-5286795 [Tardiphaga sp. 37S4]
ATGCTTGATACAAACGTCGTCTCGGATCTGATCCGAAATCCGGCGGGTCGTGTAGCCAAGAGAATTCGTAAACTCGGCGC
CGAGGGATTTTGCGTCAGCATCATTACGTCCGCCGAATTGCGGTTCGGATGCGCCAAACGTAATTCACCGCGGCTCACGC
AACTCGTAGAGCAGGTGCTGAATGAGCTCGATATCCTGCCGCTGGAAAGTCCGGCCGACACCGAATACGCCCGCATTCGC
CACGACCTTGAAAAGAAGGGCGTCCCCATCGGCCCGAATGACCTGCTGATCGCGGCTCACGCTTGCGCCGTCGATGCCAC
GCTGGTGACTGCGAATGCGAAAGAATTCAAACGGGTGAGCGGTCTGAAAGTCGAGAACTGGCTGTCATAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT185135 WP_001390338.1 NZ_CP066833:c3813640-3813263 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT185135 NZ_CP088008:5286152-5286391 [Tardiphaga sp. 37S4]
ATGACCGACTCCCGTCACGTCAGGCTATTTCGTAACGGTCGCAATCAGGCGGTCCGCATTCCCGTTGAATTCGAGTTACC
GGGTGACGAAGCTGTCATGCACCGCGACGGCGACAGGCTCGTAATCGAGCCCGTACGCAAGCGCGGCCTGCTGGCATTGC
TTGATACGATGGAGCCATTCACAGAAGAATTTCCGGACGTCGATGCAGGCCTGCGCCCGCTACGGGACATCAAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References