Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3271134..3272856 | Replicon | chromosome |
| Accession | NZ_CP066833 | ||
| Organism | Proteus mirabilis strain RGF134-1 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | JEQ15_RS15225 | Protein ID | WP_211868028.1 |
| Coordinates | 3271134..3272072 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | JEQ15_RS15230 | Protein ID | WP_223293371.1 |
| Coordinates | 3272065..3272856 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JEQ15_RS15205 (JEQ15_15150) | 3267075..3267587 | - | 513 | WP_223293369.1 | S26 family signal peptidase | - |
| JEQ15_RS15210 (JEQ15_15155) | 3267571..3267918 | - | 348 | WP_004249366.1 | hypothetical protein | - |
| JEQ15_RS15215 (JEQ15_15160) | 3267911..3270310 | - | 2400 | WP_223293370.1 | type IV secretion system protein TraC | - |
| JEQ15_RS15220 (JEQ15_15165) | 3270310..3271002 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| JEQ15_RS15225 (JEQ15_15170) | 3271134..3272072 | - | 939 | WP_211868028.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JEQ15_RS15230 (JEQ15_15175) | 3272065..3272856 | - | 792 | WP_223293371.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| JEQ15_RS15235 (JEQ15_15180) | 3273077..3273463 | - | 387 | WP_032469918.1 | TraA family conjugative transfer protein | - |
| JEQ15_RS15240 (JEQ15_15185) | 3273460..3274032 | - | 573 | WP_148039504.1 | type IV conjugative transfer system lipoprotein TraV | - |
| JEQ15_RS15245 (JEQ15_15190) | 3274107..3275396 | - | 1290 | WP_159262611.1 | TraB/VirB10 family protein | - |
| JEQ15_RS15250 (JEQ15_15195) | 3275399..3276295 | - | 897 | WP_159262630.1 | type-F conjugative transfer system secretin TraK | - |
| JEQ15_RS15255 (JEQ15_15200) | 3276279..3276905 | - | 627 | WP_159262613.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| JEQ15_RS15260 (JEQ15_15205) | 3276902..3277183 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
| JEQ15_RS15265 (JEQ15_15210) | 3277364..3277687 | + | 324 | WP_001896384.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(J) | - | 3179172..3351656 | 172484 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35578.85 Da Isoelectric Point: 4.9081
>T185132 WP_211868028.1 NZ_CP066833:c3272072-3271134 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQTKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQTKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T185132 NZ_CP088007:c5329997-5329644 [Nocardia huaxiensis]
TTGAAATTCGTCGTAGATGCCCAGCTGCCACCAGCGCTGGCCCGTGCGCTGGCTGCCGAAGGACATGAGGCTGTTCACGT
CTGCGATCTTGGAATGACCTCTGCGTCTGATCGCGAGGTATGGAACGAGGCGCTCGAGCGCGAGGCAGTCATCGTGACGA
AGGATGAAGACTTCGTCACGATCGGTCGTGCCCAGCCGAATGAGCCTGTGCCCGCGATTGTTTGGATTCGTATCGGAAAT
TGCTCGCGGAAGGCGTTGCTCGAATCGCTGTTGCCATTGCTGCCGACAGTGGTGGAGCTACTGGAGGCTGGGGAGCGCAT
CGTCGAGATACGGTCTCCGCAAACTCATTCCTGA
TTGAAATTCGTCGTAGATGCCCAGCTGCCACCAGCGCTGGCCCGTGCGCTGGCTGCCGAAGGACATGAGGCTGTTCACGT
CTGCGATCTTGGAATGACCTCTGCGTCTGATCGCGAGGTATGGAACGAGGCGCTCGAGCGCGAGGCAGTCATCGTGACGA
AGGATGAAGACTTCGTCACGATCGGTCGTGCCCAGCCGAATGAGCCTGTGCCCGCGATTGTTTGGATTCGTATCGGAAAT
TGCTCGCGGAAGGCGTTGCTCGAATCGCTGTTGCCATTGCTGCCGACAGTGGTGGAGCTACTGGAGGCTGGGGAGCGCAT
CGTCGAGATACGGTCTCCGCAAACTCATTCCTGA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30195.54 Da Isoelectric Point: 9.3573
>AT185132 WP_223293371.1 NZ_CP066833:c3272856-3272065 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYTQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRIRVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIELGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYTQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRIRVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIELGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT185132 NZ_CP088007:c5330143-5329994 [Nocardia huaxiensis]
GTGAAGGACGTTCTCGAACTCCTCGCCGCTGGTGAAACCGAGGACTCGATCCTCGAGGACTACCCGTATCTGGAGCGGGA
GGATATTCGCGCCTGCCTGGCGTTTGCCGCGGCGGAAGCAGATCACCCGATCTTGCGGCCCGCATCTTGA
GTGAAGGACGTTCTCGAACTCCTCGCCGCTGGTGAAACCGAGGACTCGATCCTCGAGGACTACCCGTATCTGGAGCGGGA
GGATATTCGCGCCTGCCTGGCGTTTGCCGCGGCGGAAGCAGATCACCCGATCTTGCGGCCCGCATCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|