Detailed information of TA system TA185128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 75853..77451
• Replicon: chromosome
• Accession: NZ_CP066833
• Organism: Proteus mirabilis strain RGF134-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JEQ15_RS00380
• Protein ID: WP_063108770.1
• Coordinates: 75853..77196 (-)
• Length: 448 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JEQ15_RS00385
• Protein ID: WP_041701484.1
• Coordinates: 77200..77451 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JEQ15_RS00360 (JEQ15_00360)	71469..72653	+	1185	WP_049220052.1	multidrug efflux MFS transporter EmrD	-
JEQ15_RS00365 (JEQ15_00365)	72764..74296	-	1533	WP_004246422.1	glycerol kinase GlpK	-
JEQ15_RS00370 (JEQ15_00370)	74339..75154	-	816	WP_004246421.1	MIP/aquaporin family protein	-
JEQ15_RS00375 (JEQ15_00375)	75451..75693	+	243	WP_012368679.1	cell division protein ZapB	-
JEQ15_RS00380 (JEQ15_00380)	75853..77196	-	1344	WP_063108770.1	type II toxin-antitoxin system HipA family toxin	Toxin
JEQ15_RS00385 (JEQ15_00385)	77200..77451	-	252	WP_041701484.1	helix-turn-helix domain-containing protein	Antitoxin
JEQ15_RS00390	77692..77957	+	266	Protein_77	IS4 family transposase	-
JEQ15_RS00395 (JEQ15_00390)	78027..78545	-	519	WP_004246419.1	ribonuclease E activity regulator RraA	-
JEQ15_RS00400 (JEQ15_00395)	78654..79571	-	918	WP_020946557.1	1,4-dihydroxy-2-naphthoate polyprenyltransferase	-
JEQ15_RS00405 (JEQ15_00400)	79670..81010	-	1341	WP_004246417.1	HslU--HslV peptidase ATPase subunit	-
JEQ15_RS00410 (JEQ15_00405)	81023..81553	-	531	WP_004246416.1	ATP-dependent protease subunit HslV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 448 a.a.
• Molecular weight: 49787.20 Da
• Isoelectric Point: 5.3203

>T185128 WP_063108770.1 NZ_CP066833:c77196-75853 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Nucleotide

• Length: 1344 bp

>T185128 NZ_CP088002:c1647764-1647402 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9390.83 Da
• Isoelectric Point: 9.8955

>AT185128 WP_041701484.1 NZ_CP066833:c77451-77200 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Nucleotide

• Length: 252 bp

>AT185128 NZ_CP088002:c1647931-1647761 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA