Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2271984..2272982 Replicon chromosome
Accession NZ_CP066812
Organism Mycobacterium avium subsp. paratuberculosis strain 42-13-1

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag MAPJR_RS10420 Protein ID WP_003876749.1
Coordinates 2272404..2272982 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID Q73Z26
Locus tag MAPJR_RS10415 Protein ID WP_003878042.1
Coordinates 2271984..2272373 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAPJR_RS10395 2267119..2267799 - 681 WP_010949357.1 hypothetical protein -
MAPJR_RS10400 2267879..2269396 + 1518 WP_015632643.1 carboxylesterase/lipase family protein -
MAPJR_RS10405 2269415..2271412 + 1998 WP_003876752.1 phosphotransferase -
MAPJR_RS10410 2271409..2271903 + 495 WP_010949355.1 gluconokinase -
MAPJR_RS10415 2271984..2272373 + 390 WP_003878042.1 hypothetical protein Antitoxin
MAPJR_RS10420 2272404..2272982 + 579 WP_003876749.1 zeta toxin family protein Toxin
MAPJR_RS10425 2272987..2274054 - 1068 WP_010949354.1 DoxX family membrane protein -
MAPJR_RS10430 2274165..2274725 + 561 WP_003878040.1 pyrazinamidase PncA -
MAPJR_RS10435 2274725..2275525 + 801 WP_003876746.1 nuclear transport factor 2 family protein -
MAPJR_RS10440 2275539..2275889 - 351 WP_003878038.1 DoxX family protein -
MAPJR_RS10445 2276209..2277429 + 1221 WP_202151988.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2276230..2277429 1199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T185122 WP_003876749.1 NZ_CP066812:2272404-2272982 [Mycobacterium avium subsp. paratuberculosis]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T185122 NZ_CP088000:c766306-765965 [Stenotrophomonas rhizophila]
ATGCACGCCGTGTTCGTGGAGATGCCGGCGTTCTCGCGCCACCGTGCCGCCTACCTCGACAACGATGGGCTCTGCGCGCT
TCAGCAGTTCCTGCTGCGGGCGCCGGAGGCTGGCGACGTGATCGTGGGTACCGGCGGTCTCCGCAAGCTGCGCTTTTCCG
ACGACCGCAGGCAGCGTGGCAAGCGGGGCGGACTACGGGTGATCTACTTCCATTGGCCGGCGGGTTCGCAGTTCTGGCTG
TTCACCCTCTACGGCAAGGGGGTCCAGGACGACCTGGACGCGATGCAGAAAAGACTGTTGAAAAGAATGCTTGAGGCCGT
ACTTCTGGCGAGGACCACATGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13569.99 Da        Isoelectric Point: 5.6717

>AT185122 WP_003878042.1 NZ_CP066812:2271984-2272373 [Mycobacterium avium subsp. paratuberculosis]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAEITAEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT185122 NZ_CP088000:c765965-765636 [Stenotrophomonas rhizophila]
ATGAAACGCGACGTATTTGCCGAGCTGGTCGAAGGACTGCACGCGCTGGAGGACGAGCGCGCGGGCAAGACCACGCTGCG
CACGCACAAGGTTCGACTGCAGCCGTTGCCCCCGCTGCATGCGGGAGAGCTGGTCGCCATCCGTGAACAGCTGAACATGT
CACGGCCGGTGTTTGCCATGTACCTGCGTACCAATGCACGCACGCTGGAGAACTGGGAGCAGGGCCGCGCGCGTCCCAAC
GCGCAGGCATCGACCCTCATTCGACTGGTGCAACAGTTTCCACAGACCGTTCGCCACCTGGAGGCGCTGCAGCCGGACGT
CGCCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2W6B4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U6EQJ5

References