Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1195171..1195735 Replicon chromosome
Accession NZ_CP066812
Organism Mycobacterium avium subsp. paratuberculosis strain 42-13-1

Toxin (Protein)


Gene name vapC Uniprot ID X7VBD8
Locus tag MAPJR_RS05755 Protein ID WP_003875391.1
Coordinates 1195364..1195735 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7L5MGM2
Locus tag MAPJR_RS05750 Protein ID WP_003875390.1
Coordinates 1195171..1195377 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAPJR_RS05730 1190424..1191422 + 999 WP_003875386.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MAPJR_RS05735 1191446..1192654 - 1209 WP_010949696.1 hypothetical protein -
MAPJR_RS05740 1192785..1193858 + 1074 WP_010949695.1 redox-regulated ATPase YchF -
MAPJR_RS05745 1194058..1195002 + 945 WP_003875389.1 HNH endonuclease -
MAPJR_RS05750 1195171..1195377 + 207 WP_003875390.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MAPJR_RS05755 1195364..1195735 + 372 WP_003875391.1 type II toxin-antitoxin system VapC family toxin Toxin
MAPJR_RS05760 1195835..1196275 + 441 WP_010949694.1 nitroreductase family deazaflavin-dependent oxidoreductase -
MAPJR_RS05765 1196331..1196606 + 276 WP_003878531.1 hypothetical protein -
MAPJR_RS05770 1196708..1197106 + 399 WP_003875394.1 VOC family protein -
MAPJR_RS05775 1197173..1197556 + 384 WP_003875395.1 hypothetical protein -
MAPJR_RS05780 1197626..1197979 + 354 WP_003875396.1 hypothetical protein -
MAPJR_RS05785 1198136..1198660 + 525 WP_033713819.1 glycoside hydrolase -
MAPJR_RS05790 1199071..1199395 + 325 Protein_1146 antibiotic biosynthesis monooxygenase -
MAPJR_RS05795 1199400..1200083 - 684 WP_003875399.1 hypothetical protein -
MAPJR_RS05800 1200201..1200398 + 198 WP_016706054.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13770.14 Da        Isoelectric Point: 6.6003

>T185120 WP_003875391.1 NZ_CP066812:1195364-1195735 [Mycobacterium avium subsp. paratuberculosis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Download         Length: 372 bp

>T185120 NZ_CP087999:4219030-4219353 [Geomonas sp. RF6]
ATGGTGACAAAGCGCTTCGAGGTCTATCTGGTGAATCTTGATCCGACTGTCGGAAGTGAGATTCGGAAGGCCCGACCGTG
TCTCATAATCTCTCCGGACGAGATGAACCGTTTTCTTGCAACTGTAATTGTTGCGCCGATGACCACTAAGGGAAGGGATT
ACCCAACGCGGGTACCTTGCTCGTTCAAAGGAAAGGACGGGCACGTAGTGCTTGATCAACTGAGAACGGTGGACAAGATC
CGGCTCGTGCAAAAGCTTGGAAAGGTGAAACCACAAACTCAGCAGGATGTGCTGGCAGTGTTGTCCGACATGTTCGCGGA
GTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7231.22 Da        Isoelectric Point: 11.0634

>AT185120 WP_003875390.1 NZ_CP066812:1195171-1195377 [Mycobacterium avium subsp. paratuberculosis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRAPADDSR

Download         Length: 207 bp

>AT185120 NZ_CP087999:4218782-4219036 [Geomonas sp. RF6]
ATGAGGGCAAGTATCATCCGTATCGGGAATTCTCAGGGGATAAGGATCCCAAAGCTCCTTCTTGAGCAAACGAGACTCGG
AAGTGAGGTTGAACTCGAAGTCGAAGACGACAAGATAGTGATTCGGCCGGTATCCCGACCACGACAGGGCTGGCTTGAAA
AGTTTAAACTCATGGCAGAGCAGGGTGACGACCGGCTGCTGGACCCGGGCGCTGGGGAAGAGACGGAGTGGGATAAGGAT
GAATGGGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2WB37

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5MGM2

References