Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2729198..2729993 | Replicon | chromosome |
| Accession | NZ_CP066809 | ||
| Organism | Shigella flexneri 3a strain 888048 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | JGY96_RS13945 | Protein ID | WP_000854914.1 |
| Coordinates | 2729198..2729572 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7U9LM11 |
| Locus tag | JGY96_RS13950 | Protein ID | WP_001280953.1 |
| Coordinates | 2729619..2729993 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JGY96_RS13905 (2724202) | 2724202..2724693 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| JGY96_RS13910 (2724795) | 2724795..2725349 | - | 555 | WP_001001917.1 | molecular chaperone YcdY | - |
| JGY96_RS13915 (2725373) | 2725373..2726110 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| JGY96_RS13920 (2726165) | 2726165..2727103 | - | 939 | Protein_2722 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| JGY96_RS13930 (2727574) | 2727574..2728416 | - | 843 | WP_053884962.1 | DUF4942 domain-containing protein | - |
| JGY96_RS13935 (2728501) | 2728501..2728698 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| JGY96_RS13940 (2728710) | 2728710..2729201 | - | 492 | WP_000976857.1 | DUF5983 family protein | - |
| JGY96_RS13945 (2729198) | 2729198..2729572 | - | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| JGY96_RS13950 (2729619) | 2729619..2729993 | - | 375 | WP_001280953.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JGY96_RS13955 (2730156) | 2730156..2730377 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| JGY96_RS13960 (2730440) | 2730440..2730916 | - | 477 | WP_001186738.1 | RadC family protein | - |
| JGY96_RS13965 (2730932) | 2730932..2731417 | - | 486 | WP_000214398.1 | antirestriction protein | - |
| JGY96_RS13970 (2731508) | 2731508..2731978 | - | 471 | Protein_2731 | DUF945 domain-containing protein | - |
| JGY96_RS13975 (2732021) | 2732021..2733233 | - | 1213 | Protein_2732 | IS3 family transposase | - |
| JGY96_RS13980 (2733287) | 2733287..2733728 | + | 442 | Protein_2733 | IS200/IS605 family transposase | - |
| JGY96_RS13985 (2733846) | 2733846..2734784 | - | 939 | WP_052961806.1 | hypochlorite stress DNA-binding transcriptional regulator HypT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | ant(3'')-Ia / blaOXA-1 / catA1 / tet(B) | csgC / csgA / csgB / csgD / csgE / csgF / csgG | 2717713..2782700 | 64987 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T185115 WP_000854914.1 NZ_CP066809:c2729572-2729198 [Shigella flexneri 3a]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T185115 NZ_CP087997:4267846-4268283 [Subtercola sp. AK-R2A1-2]
GTGATTCTCGACACGTCGGCTGTGATCCTCGACACGTCGGCTGTGGTCCTCGACACGTCGGCTGTGATCGCGCTGGTCAA
CCGAGAGCCCGAGTGGCGCGCGGTGTTCGATCGCATCGATGGTGCAGGCGAGGTACGGATGAGCTCCGTGAGTCTCTTGG
AGTTGTCTATCGTGCTCGGTTCTCCGCGATTCGGCATGAGCCGAAGCGAGGTCGCGGCCCTTCTTGAATCGATGGGCGTG
GCGACCGTTGCGTTCACCCCAGACCACGCCGTGCTGGCTGCCGAGGCCTACGCCCGCTACGGCAAGGGCAACCATCCGGC
CCGGCTGGACTTCGGCGATTGTGCGGCGTATGCGACGGCCGTGCTCGACGGCGGCAGTCTGCTGTTCGTCGGCGAGGATT
TCGTCCAGACCGACGTGCGCTCGGCGCTCGGCGAGTAA
GTGATTCTCGACACGTCGGCTGTGATCCTCGACACGTCGGCTGTGGTCCTCGACACGTCGGCTGTGATCGCGCTGGTCAA
CCGAGAGCCCGAGTGGCGCGCGGTGTTCGATCGCATCGATGGTGCAGGCGAGGTACGGATGAGCTCCGTGAGTCTCTTGG
AGTTGTCTATCGTGCTCGGTTCTCCGCGATTCGGCATGAGCCGAAGCGAGGTCGCGGCCCTTCTTGAATCGATGGGCGTG
GCGACCGTTGCGTTCACCCCAGACCACGCCGTGCTGGCTGCCGAGGCCTACGCCCGCTACGGCAAGGGCAACCATCCGGC
CCGGCTGGACTTCGGCGATTGTGCGGCGTATGCGACGGCCGTGCTCGACGGCGGCAGTCTGCTGTTCGTCGGCGAGGATT
TCGTCCAGACCGACGTGCGCTCGGCGCTCGGCGAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13734.56 Da Isoelectric Point: 6.6249
>AT185115 WP_001280953.1 NZ_CP066809:c2729993-2729619 [Shigella flexneri 3a]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS
Download Length: 375 bp
>AT185115 NZ_CP087997:4267592-4267849 [Subtercola sp. AK-R2A1-2]
ATGGGTCTCAACCTGAAAGACGACGAAACCGTTGCACTCGTTTCAGAGGTCGCCAGGCGTCTCGGTCTGACGAAGACCGG
CGCCGTGCGCGAGTTGGCGCGAGCCAAGCTGGCCGATCTCGACGCGCAGAGCGCCCTCAAGAGCTCCACTCTGCTTCGAT
ATCTCGAGTCAGAGGTGTGGCCGCACACCGTCGGCGCACCTGTGTCGAAGACCGAGCGCGAGAGCATTGTCGGTTATGAC
GAAATGCTCTCGGTGTGA
ATGGGTCTCAACCTGAAAGACGACGAAACCGTTGCACTCGTTTCAGAGGTCGCCAGGCGTCTCGGTCTGACGAAGACCGG
CGCCGTGCGCGAGTTGGCGCGAGCCAAGCTGGCCGATCTCGACGCGCAGAGCGCCCTCAAGAGCTCCACTCTGCTTCGAT
ATCTCGAGTCAGAGGTGTGGCCGCACACCGTCGGCGCACCTGTGTCGAAGACCGAGCGCGAGAGCATTGTCGGTTATGAC
GAAATGCTCTCGGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LXR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LM11 |