Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2288018..2288544 | Replicon | chromosome |
| Accession | NZ_CP066809 | ||
| Organism | Shigella flexneri 3a strain 888048 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | JGY96_RS11605 | Protein ID | WP_000323025.1 |
| Coordinates | 2288018..2288305 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | JGY96_RS11610 | Protein ID | WP_000534858.1 |
| Coordinates | 2288305..2288544 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JGY96_RS11555 (2283078) | 2283078..2283413 | + | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
| JGY96_RS11560 (2283694) | 2283694..2283780 | - | 87 | WP_000115835.1 | DUF3927 family protein | - |
| JGY96_RS11575 (2284722) | 2284722..2285543 | - | 822 | WP_000762884.1 | antitermination protein | - |
| JGY96_RS11580 (2285558) | 2285558..2285914 | - | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| JGY96_RS11585 (2285927) | 2285927..2286976 | - | 1050 | WP_025759563.1 | DUF968 domain-containing protein | - |
| JGY96_RS11590 (2286978) | 2286978..2287256 | - | 279 | WP_024258459.1 | hypothetical protein | - |
| JGY96_RS11595 (2287323) | 2287323..2287573 | - | 251 | Protein_2263 | hypothetical protein | - |
| JGY96_RS11600 (2287791) | 2287791..2287946 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| JGY96_RS11605 (2288018) | 2288018..2288305 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| JGY96_RS11610 (2288305) | 2288305..2288544 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| JGY96_RS11615 (2288569) | 2288569..2288874 | + | 306 | WP_071818640.1 | hypothetical protein | - |
| JGY96_RS11620 (2288871) | 2288871..2290027 | - | 1157 | Protein_2268 | IS3 family transposase | - |
| JGY96_RS11625 (2290091) | 2290091..2290449 | + | 359 | Protein_2269 | type 1 fimbrial protein | - |
| JGY96_RS11630 (2290462) | 2290462..2290827 | + | 366 | Protein_2270 | type 1 fimbrial protein | - |
| JGY96_RS11635 (2290902) | 2290902..2291111 | - | 210 | Protein_2271 | IS1 family transposase | - |
| JGY96_RS11640 (2291176) | 2291176..2292332 | - | 1157 | Protein_2272 | IS3 family transposase | - |
| JGY96_RS11645 (2292435) | 2292435..2292925 | - | 491 | Protein_2273 | IS1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2252957..2292731 | 39774 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T185114 WP_000323025.1 NZ_CP066809:c2288305-2288018 [Shigella flexneri 3a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T185114 NZ_CP087997:3927218-3927580 [Subtercola sp. AK-R2A1-2]
GTGAGGCGCGGACACGTCGTTGCCGTCAGGCTCGACCCAGCCGAGCCAGGCGAGGCAGCGAAGACGCGACCATGTTTGGT
CGTCAGCAACGACGGCGCGAATGAATCGGCAACCAGCGTGGGGCGTGGAACCATCACGATCGTGCCGGTGACCACCAACG
TGTCGAATGCACACGGTGAGTTTCAGGTTCTCGTCGATGACGCGGAGGTGCTCGAGTCGATGGGGCTGTCGAGTACGTCG
AAGATCCAGGCAGAGCAGGTGCGAACGGTTTCCGTCGAACGCCTTTCAGGAATCCGCGGCTATGCGCCGGGGTGGATCAT
GCAGCAGGTCGATCACGCTTTGAGATTTCACCTGTCGTTGTAG
GTGAGGCGCGGACACGTCGTTGCCGTCAGGCTCGACCCAGCCGAGCCAGGCGAGGCAGCGAAGACGCGACCATGTTTGGT
CGTCAGCAACGACGGCGCGAATGAATCGGCAACCAGCGTGGGGCGTGGAACCATCACGATCGTGCCGGTGACCACCAACG
TGTCGAATGCACACGGTGAGTTTCAGGTTCTCGTCGATGACGCGGAGGTGCTCGAGTCGATGGGGCTGTCGAGTACGTCG
AAGATCCAGGCAGAGCAGGTGCGAACGGTTTCCGTCGAACGCCTTTCAGGAATCCGCGGCTATGCGCCGGGGTGGATCAT
GCAGCAGGTCGATCACGCTTTGAGATTTCACCTGTCGTTGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT185114 WP_000534858.1 NZ_CP066809:c2288544-2288305 [Shigella flexneri 3a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT185114 NZ_CP087997:3926997-3927221 [Subtercola sp. AK-R2A1-2]
ATGACTACCAAGCTGAGCGTGAGTCTCTCGGAGAGCGACGTCGAGTACATCGACGAATTGGCACGTGCCAAATCGGGCAA
CCGCTCGGCCGTCATTCACGACCTTGTTCGCATTGCCCGTGAGAAGCGCGCGGTAAGCGACTATTCCCTAGCTGCGGATG
AGTGGGCGAGTTCAGGCGATGCGAAGCTGTGGGAGGGAACGGCGTCTGACGGTCTCAGCGCGTGA
ATGACTACCAAGCTGAGCGTGAGTCTCTCGGAGAGCGACGTCGAGTACATCGACGAATTGGCACGTGCCAAATCGGGCAA
CCGCTCGGCCGTCATTCACGACCTTGTTCGCATTGCCCGTGAGAAGCGCGCGGTAAGCGACTATTCCCTAGCTGCGGATG
AGTGGGCGAGTTCAGGCGATGCGAAGCTGTGGGAGGGAACGGCGTCTGACGGTCTCAGCGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|