Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 844876..845530 Replicon chromosome
Accession NZ_CP066809
Organism Shigella flexneri 3a strain 888048

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag JGY96_RS04210 Protein ID WP_000244767.1
Coordinates 845123..845530 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag JGY96_RS04205 Protein ID WP_000354044.1
Coordinates 844876..845142 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY96_RS04180 (840045) 840045..840788 + 744 WP_119182047.1 SDR family oxidoreductase -
JGY96_RS04185 (840845) 840845..842278 - 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
JGY96_RS04190 (842323) 842323..842634 + 312 WP_001182950.1 N(4)-acetylcytidine aminohydrolase -
JGY96_RS04195 (842798) 842798..843457 + 660 WP_000250274.1 hemolysin III family protein -
JGY96_RS04200 (843653) 843653..844633 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JGY96_RS04205 (844876) 844876..845142 + 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
JGY96_RS04210 (845123) 845123..845530 + 408 WP_000244767.1 protein YgfX Toxin
JGY96_RS04215 (845570) 845570..846091 - 522 WP_001055867.1 flavodoxin FldB -
JGY96_RS04220 (846203) 846203..847099 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JGY96_RS04225 (847124) 847124..847834 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JGY96_RS04230 (847840) 847840..849573 + 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T185100 WP_000244767.1 NZ_CP066809:845123-845530 [Shigella flexneri 3a]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T185100 NZ_CP087994:888424-888600 [Acetobacterium wieringae]
ATGAAAGACAAAGACTTACTCAAATTACTTGAGAAAAATGGATGGGTTGAAGAACGAATCAAAGGTAGCCATCATGTCAT
GAAAAAAGATGGTAAAACTGAGATCATCCCTGTTCATGGAAAAGACATCCCAACTGGCTTACAAAAAACAATTCTGAAAA
GGACAGGGTTGAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT185100 WP_000354044.1 NZ_CP066809:844876-845142 [Shigella flexneri 3a]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185100 NZ_CP087994:888633-889019 [Acetobacterium wieringae]
ATGTTAAGTGCATATCCAGCAATTTTTCACAAAGAAGATGGTACCTACTGGGTAGAGTTTCCAGATCTTCCTGGTTGCCA
GACTGTTGGCGAAAGTATTGGTGAAGTGATGGAAGAAGCTCAGGAAGCATTAGGGTTGTATTTGGCATCATTAATCGAAG
ATGAAGAAGAGATTAATCCGGCTTCTGATATTAAAGGTATCGTTGCTGAAGATGATTCATTCACAAGTCTCGTCGCCTGT
GATCTAACTCAATATGTAAGATCTGCTAAAGCTGTGAAAAAGACCTTAACCATCCCCGATTGGCTCAATAACATGGCTGA
AAAGAACAGCATTAATTTTTCTCAAACACTACAAAAAGCACTTATGGAAAAACTGCACATTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References