Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4097478..4098028 Replicon chromosome
Accession NZ_CP066806
Organism Escherichia coli strain TCM3e1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JGU77_RS19535 Protein ID WP_075861930.1
Coordinates 4097478..4097792 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag JGU77_RS19540 Protein ID WP_075861929.1
Coordinates 4097795..4098028 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGU77_RS19510 4093153..4094439 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
JGU77_RS19515 4094439..4095428 + 990 WP_075861933.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
JGU77_RS19520 4095425..4096246 + 822 WP_075861932.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
JGU77_RS19525 4096249..4096626 + 378 WP_169781281.1 Co2+/Mg2+ efflux protein ApaG -
JGU77_RS19530 4096633..4097481 + 849 WP_075861931.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
JGU77_RS19535 4097478..4097792 - 315 WP_075861930.1 CcdB family protein Toxin
JGU77_RS19540 4097795..4098028 - 234 WP_075861929.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JGU77_RS19545 4098114..4098593 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
JGU77_RS19550 4098785..4100647 - 1863 WP_000377117.1 glutathione-regulated potassium-efflux system protein KefC -
JGU77_RS19555 4100640..4101170 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
JGU77_RS19560 4101278..4102609 - 1332 WP_001183201.1 MFS transporter -
JGU77_RS19565 4102667..4102954 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11755.77 Da        Isoelectric Point: 9.0851

>T185083 WP_075861930.1 NZ_CP066806:c4097792-4097478 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIISEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T185083 NZ_CP087992:c475657-475403 [Xylella fastidiosa subsp. multiplex]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGGCTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8618.59 Da        Isoelectric Point: 5.0789

>AT185083 WP_075861929.1 NZ_CP066806:c4098028-4097795 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAETRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT185083 NZ_CP087992:c475406-475071 [Xylella fastidiosa subsp. multiplex]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGACAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References