Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2751613..2752230 Replicon chromosome
Accession NZ_CP066803
Organism Pantoea ananatis strain LCFJ-001

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag JGU81_RS12780 Protein ID WP_013024903.1
Coordinates 2752015..2752230 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag JGU81_RS12775 Protein ID WP_015700827.1
Coordinates 2751613..2751990 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGU81_RS12745 2747897..2748151 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
JGU81_RS12750 2748163..2748303 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
JGU81_RS12755 2748363..2749241 - 879 WP_013024908.1 metal ABC transporter substrate-binding protein -
JGU81_RS12760 2749254..2750093 - 840 WP_013024907.1 metal ABC transporter permease -
JGU81_RS12765 2750090..2750758 - 669 WP_200286633.1 ABC transporter ATP-binding protein -
JGU81_RS12770 2751113..2751466 + 354 WP_013024905.1 hypothetical protein -
JGU81_RS12775 2751613..2751990 + 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
JGU81_RS12780 2752015..2752230 + 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
JGU81_RS12790 2752628..2752939 + 312 WP_014606432.1 MGMT family protein -
JGU81_RS12795 2752988..2753545 - 558 WP_019106636.1 YbaY family lipoprotein -
JGU81_RS12800 2753738..2754601 + 864 WP_116219510.1 acyl-CoA thioesterase II -
JGU81_RS12805 2754648..2755937 - 1290 WP_116219509.1 ammonium transporter AmtB -
JGU81_RS12810 2755972..2756310 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T185059 WP_013024903.1 NZ_CP066803:2752015-2752230 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T185059 NZ_CP087952:2114466-2114762 [Desulfosarcina sp. BuS5]
ATGATTAAGAATTTTCGTGATAATTGGCTACGAAAGTTTTTCGTGGAGGACATTCAGGCAAAAAAAATACCCGCTGATAT
TCGTTCACGATTGTTTAGGAAATTACAACTGTTGGATGATGCAACGAATGATGCTGACTTGAGAAGTCCACCCAGCAATC
ATTTTGAAAAATTATCTGGCAAATTAAAAGATAAATGCTCCATACGTGTCAATGACCAATGGCGTTTAATTTTTACTTGG
GATGATGAACACGGGGAGGCGAATGACATTTATATTGATGATCATTCATATAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT185059 WP_015700827.1 NZ_CP066803:2751613-2751990 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT185059 NZ_CP087952:2114771-2115082 [Desulfosarcina sp. BuS5]
ATGATTATAACTAAACGTAAACCCGTCAGTGTCGGTGAAATGATTAATGAAGAATTTATTGCACCTTTGGGAATTACTCA
GGGGCAACTATCTTCTGCAATGGGCGTCAGTCGAAGAACTGTAAATGAACTTTGCACTGGTAAGAGATCTATAACCGTTG
ATACTGCTTTAATGTTAGCTAAAGTATTTGGAAATACAGCGAATTTTTGGCTTAATTTACAGCAACGAAATGATATATGG
GCTGCACTACATTCCCCGAAGCGAATGGAAAAAATTGAGCGTGTTAGTCCAATTCGTGAAGCAATTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References