Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1241087..1241677 Replicon chromosome
Accession NZ_CP066803
Organism Pantoea ananatis strain LCFJ-001

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JGU81_RS05585 Protein ID WP_019106594.1
Coordinates 1241345..1241677 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JGU81_RS05580 Protein ID WP_105076879.1
Coordinates 1241087..1241344 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGU81_RS05560 1236373..1236798 + 426 WP_200286898.1 pentapeptide repeat-containing protein -
JGU81_RS05565 1237086..1238324 - 1239 WP_042678145.1 MFS transporter -
JGU81_RS05570 1239072..1240034 + 963 WP_041930826.1 ferrochelatase -
JGU81_RS05575 1240534..1240739 + 206 Protein_1085 helix-turn-helix domain-containing protein -
JGU81_RS05580 1241087..1241344 + 258 WP_105076879.1 antitoxin Antitoxin
JGU81_RS05585 1241345..1241677 + 333 WP_019106594.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGU81_RS05595 1241938..1242771 - 834 WP_105076880.1 DgsA anti-repressor MtfA -
JGU81_RS05600 1242877..1243554 - 678 WP_013026204.1 hypothetical protein -
JGU81_RS05605 1244166..1244870 + 705 WP_022623305.1 phosphohydrolase -
JGU81_RS05610 1244944..1245198 + 255 WP_013026202.1 Arc family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11931.63 Da        Isoelectric Point: 6.9802

>T185048 WP_019106594.1 NZ_CP066803:1241345-1241677 [Pantoea ananatis]
MDRGEIWLVSLDPNAGHEQSGRRPVLIVSPASFNQFTRLPVVVPVTNGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMEARNGKYLERIPEVIVNEVVARLEAILS

Download         Length: 333 bp

>T185048 NZ_CP087952:c717968-716664 [Desulfosarcina sp. BuS5]
ATGAGTCAGGTTGCCGAAGTTAAACTCTGGGAGCGTACAATAGGAGCGCTATCTCTTGAAGAAGGTAAGGAGGTGGCCGA
TTTTGAGTATGATCCGGCTTTTGCCGGCAGCGGGATTGAGATAGCGCCTCTGACAATGCCCCTTGCTAATAGAGTTTATT
CCTTTCCTGAATTATCCAGAATGACTTTTCGCGGACTCCCGGGATTGATAGCTGATTCGTTGCCGGACAGATTCGGCCAT
GCTCTCATTGATGTCTGGCTGGCCACTCGCGGACAACCACCGGAATCGTTTAATGCCGTTGAACGTCTCTGCTATATTGG
CAGAAGGGGAATGGGTGCCCTGGAGTTTGAGCCCGCCATAGGACCGAAAGCCCGCAAGTCCACCCGCGTTCAAGTCGATA
AACTCGTTGAGCTCGCATCGGAAATTCTGACACATCGCAAAAATCTGAAGGTATCCTTTGCCGGCAAAAAAAAGGAACGG
GCCCTAAGAGAAATTCTGAAAGTCGGTACCTCGGCAGGCGGCGCAAGGGCAAAGGCTGTAATTGCCTGGAATCCATTAAC
CAATGAAGTGCGATCCGGTCAGATCCCGGCGGGTGAAGGTTTTGAGTATTGGTTGCTTAAATTTGATGGTGTTAAGGGCA
ACAAGGATAAAGAAATCGAGGACCCAAAAGGGTATGGGGTAATTGAATATACCTATTACAAGATGGCAACCGATGCCGGA
ATAACCATGAGTGAATGCCGGCTATTCGAAGAGAACAACAGGCGGCATTTCATGACCAGGCGCTTTGATCGACTCGACAA
CGGGGAAAAGTTACATATGCAGTCTCTATGTGCGCTGGCGCATTACGATTTCAATATGGCCGGGGCCTATGCCTACGAGC
AGGCGCTGCTCGTCATCAGGCAACTGGGTCTGCCTATGAGTGCGATTGAGGAACAGTTTCGCAGGATGGCCTTCAACATC
ATTTCGCGGAACCAGGACGATCATGTGAAAAATATAGCCTTCCTGATGGATAAATCAGGAAAATGGTCGCTTTCTCCGGC
CTTTGACATCACTTACAGCTTTAATCCTTCCGGCAAATGGACAGTTAGCCACCAGATGACGATGAACGGCAAGCGCGATA
ACTTTAGAATGGAAGACTTCAAAGCATGCGCCATGGTTGCCTCGATGAAGCGGGGACGCGCCGAGACGATTGTTAACGAG
GTGCTTAAAACAGTATCGCGCTGGAGAGATTATGCAGATGAAGCCGGAGTTTCCCCTTTATGGCGAGACGGGATTCAACA
GACACTTCGCCTGAAAATATTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9225.67 Da        Isoelectric Point: 4.4142

>AT185048 WP_105076879.1 NZ_CP066803:1241087-1241344 [Pantoea ananatis]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDSGCLIIEPQKRPRYSLEELLAQCDPHAEISEEGQEWIDAPAV
GKELL

Download         Length: 258 bp

>AT185048 NZ_CP087952:c718315-717965 [Desulfosarcina sp. BuS5]
ATGTTTAACTTTAAAACAATGACGGATGATGCTGTTCTTGAAGAGCTTGGCAGGCGGCTTGAACGTCGACGGATTGATCT
TAAGCTAACACAAGCGAAATTAGCCGAGCAGGCCGGTGTGTCCAAGAGAACGCTTGAACGGATGGAAGCCGGGGCTGTGA
CGCAAACGCGGAACCTCATTCGTATCCTTCGGATGCTCGATCTCCTGCAGGGTTTCGAGCAACTGATTCCTGTGACCGGC
CCAAGCCCCATGGACCTGCTTAAATTTAAAGGAAAGGAGCGAAAGCGCGCCTCGTCAAGCAGCGCCGTGAAACAGTCCCC
TAAAACCTGGTCCTGGGGTGATGACTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References