Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1899032..1899644 Replicon chromosome
Accession NZ_CP066796
Organism Erwinia amylovora strain ATCC 15580

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag JGC47_RS08805 Protein ID WP_012906750.1
Coordinates 1899032..1899211 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag JGC47_RS08810 Protein ID WP_004157632.1
Coordinates 1899234..1899644 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC47_RS08785 1894590..1895540 + 951 WP_004157624.1 DUF1471 domain-containing protein -
JGC47_RS08790 1895748..1897139 + 1392 WP_004157625.1 amino acid permease -
JGC47_RS08795 1897143..1897607 - 465 WP_004157626.1 hypothetical protein -
JGC47_RS08800 1897784..1898512 + 729 WP_004157629.1 two-component system response regulator RstA -
JGC47_RS08805 1899032..1899211 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
JGC47_RS08810 1899234..1899644 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JGC47_RS08815 1899700..1900701 + 1002 WP_004157633.1 acyltransferase -
JGC47_RS08820 1901572..1901784 - 213 WP_004157635.1 hypothetical protein -
JGC47_RS08825 1902042..1902215 - 174 WP_004157636.1 hypothetical protein -
JGC47_RS08830 1902310..1902483 - 174 WP_013036045.1 hypothetical protein -
JGC47_RS08835 1902494..1902766 - 273 WP_004157637.1 hypothetical protein -
JGC47_RS08840 1903372..1903986 + 615 WP_004166850.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1893236..1903986 10750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T185042 WP_012906750.1 NZ_CP066796:1899032-1899211 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T185042 NZ_CP087880:4070253-4070405 [Pseudocitrobacter corydidari]
ATGCCGCAAAAATATTTGTTATTTGGCTTAGTCGTGATTTGTTTCACGCTATTATTATTTACCTGGATGGTGAGAGATTC
ACTGTGTGAATTGCATATCAAACAGGGAAATAATGAGCTGGCGGCATTTTTAGCCTGTGGAAATAAAAAGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT185042 WP_004157632.1 NZ_CP066796:1899234-1899644 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT185042 NZ_CP087880:c4070202-4070148 [Pseudocitrobacter corydidari]
GTTGATGCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References