Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1084036..1084663 Replicon chromosome
Accession NZ_CP066796
Organism Erwinia amylovora strain ATCC 15580

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag JGC47_RS05005 Protein ID WP_004156337.1
Coordinates 1084036..1084254 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JGC47_RS05010 Protein ID WP_013035913.1
Coordinates 1084274..1084663 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC47_RS04975 1080022..1080360 + 339 WP_004156319.1 P-II family nitrogen regulator -
JGC47_RS04980 1080378..1081679 + 1302 WP_004172214.1 ammonium transporter AmtB -
JGC47_RS04985 1081754..1082614 - 861 WP_004156324.1 acyl-CoA thioesterase II -
JGC47_RS04990 1082839..1083396 + 558 WP_004156333.1 YbaY family lipoprotein -
JGC47_RS04995 1083419..1083736 - 318 WP_004156334.1 MGMT family protein -
JGC47_RS05005 1084036..1084254 - 219 WP_004156337.1 hemolysin expression modulator Hha Toxin
JGC47_RS05010 1084274..1084663 - 390 WP_013035913.1 Hha toxicity modulator TomB Antitoxin
JGC47_RS05015 1084810..1085163 - 354 WP_004156342.1 hypothetical protein -
JGC47_RS05020 1085935..1086081 - 147 WP_004156349.1 type B 50S ribosomal protein L36 -
JGC47_RS05025 1086069..1086350 - 282 WP_004156350.1 type B 50S ribosomal protein L31 -
JGC47_RS05030 1086498..1089643 - 3146 Protein_979 multidrug efflux RND transporter permease subunit AcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T185040 WP_004156337.1 NZ_CP066796:c1084254-1084036 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

>T185040 NZ_CP087880:4069173-4069325 [Pseudocitrobacter corydidari]
ATGCCGCAAAAATATTTGTTATTTGGCTTAGTCGTGATTTGTTTCACGCTATTATTATTTACCTGGATGGTGAGAGATTC
ACTGTGTGAATTGCATATAAAACAGGGAAGTAATGAGCTGGCGGCATTTTTAGCCTGTGGAAATAAAAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14965.70 Da        Isoelectric Point: 4.7040

>AT185040 WP_013035913.1 NZ_CP066796:c1084663-1084274 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Download         Length: 390 bp

>AT185040 NZ_CP087880:c4069116-4069068 [Pseudocitrobacter corydidari]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References