Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 725645..726311 Replicon chromosome
Accession NZ_CP066796
Organism Erwinia amylovora strain ATCC 15580

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag JGC47_RS03325 Protein ID WP_004161808.1
Coordinates 725892..726311 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag JGC47_RS03320 Protein ID WP_004155593.1
Coordinates 725645..725911 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC47_RS03300 722155..722847 + 693 WP_004155586.1 SDR family oxidoreductase -
JGC47_RS03305 722952..723560 - 609 WP_004155587.1 HD domain-containing protein -
JGC47_RS03310 723773..724432 + 660 WP_004155588.1 hemolysin III family protein -
JGC47_RS03315 724433..725419 - 987 WP_004155590.1 tRNA-modifying protein YgfZ -
JGC47_RS03320 725645..725911 + 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
JGC47_RS03325 725892..726311 + 420 WP_004161808.1 hypothetical protein Toxin
JGC47_RS03330 726429..726947 - 519 WP_004155596.1 flavodoxin FldB -
JGC47_RS03335 727177..728130 - 954 WP_004155597.1 DMT family transporter -
JGC47_RS03340 728640..730319 - 1680 WP_004155599.1 type III effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T185039 WP_004161808.1 NZ_CP066796:725892-726311 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T185039 NZ_CP087880:4038779-4038964 [Pseudocitrobacter corydidari]
GTGAAGAGCGCGGAGGTTATTGCAATCCTGAAACAGCACGGCTCGGTACATGTTCGTACCCGGGGAAGCCATCAGCAGTT
TCATCATCCCAGCCGAGCGGGGCTGGTTACTGTCCCACATCCCCGCAAAGATATTAAACCGGGAACCCTGGCCCAGATTT
GCCGCCAGGCCGGGATAAAAATGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT185039 WP_004155593.1 NZ_CP066796:725645-725911 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT185039 NZ_CP087880:4038981-4039388 [Pseudocitrobacter corydidari]
ATGTTCTATCCGGCTTATATACACACCGACCCCGATGGCAGCAGCAGCGGTTTTTTCCCTGATGTACCGGGTTGTTATTT
TGCGGGGGATACTCTTGATGACACCTTTCAGGATGCGCGAGGGGCGTTGGTTGCGCATTTTGAAGCGCTTTGTGAGCTTA
ATAAAGAATTGCCCTTACCGGGTTCTGTGGAAACGCATCTGGCTTGCGATCCACAAAACTATGCTGGTGGGCAGTGGTTG
CTGGTCGACATCAATATGAATCAGTTTGAGGGCAAAGCCGAACGGATCAATATCACAATGCCGAAACGGCTTCTGCAAAA
GATTGACGCGTTTGTACGTCACAATCCTGACTATGCCAACAGAAGCGCGTTTCTGGCCGAGGCTGCACGGCGAGTGTTGC
CGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References