Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1898616..1899228 Replicon chromosome
Accession NZ_CP066794
Organism Erwinia amylovora strain 17-2187

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag JGC41_RS08790 Protein ID WP_012906750.1
Coordinates 1898616..1898795 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag JGC41_RS08795 Protein ID WP_004157632.1
Coordinates 1898818..1899228 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGC41_RS08770 1894174..1895124 + 951 WP_004157624.1 DUF1471 domain-containing protein -
JGC41_RS08775 1895332..1896723 + 1392 WP_004157625.1 amino acid permease -
JGC41_RS08780 1896727..1897191 - 465 WP_004157626.1 hypothetical protein -
JGC41_RS08785 1897368..1898096 + 729 WP_004157629.1 two-component system response regulator RstA -
JGC41_RS08790 1898616..1898795 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
JGC41_RS08795 1898818..1899228 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JGC41_RS08800 1899284..1900285 + 1002 WP_004157633.1 acyltransferase -
JGC41_RS08805 1901156..1901368 - 213 WP_004157635.1 hypothetical protein -
JGC41_RS08810 1901626..1901799 - 174 WP_004157636.1 hypothetical protein -
JGC41_RS08815 1901894..1902067 - 174 WP_013036045.1 hypothetical protein -
JGC41_RS08820 1902078..1902350 - 273 WP_004157637.1 hypothetical protein -
JGC41_RS08825 1902956..1903570 + 615 WP_004166850.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1892454..1903570 11116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T185032 WP_012906750.1 NZ_CP066794:1898616-1898795 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T185032 NZ_CP087880:c3208262-3207975 [Pseudocitrobacter corydidari]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGCAATCGGGTGAAGCATGGCATCCGGTTTGAAGACGCGGT
GTTGGTGTTTGACGATCCCCGACATTTATCAAGACAGGATCGCGTAGAAAACGGAGAGTATCGCTGGCAAACCATCGGCC
TGGTACACGGCATCGTGGTTATTTTGGTCGCGCATACCATCCGTTTCGAAAGTGGAAATGAAATGATTCGAATCATCAGC
GCACGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT185032 WP_004157632.1 NZ_CP066794:1898818-1899228 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT185032 NZ_CP087880:c3207988-3207686 [Pseudocitrobacter corydidari]
ATGAGCATGGTTAAACATAAACGAGGTTCGTCCTCCACACTCAATTCTCAGCATGAAGCTGAACTCAAGGCGCTGGCGAA
TAAACCCGATGAGGATATTGATTACACCGACATACCTGCTTCCGGCGATGAACAATGGTCGGATGCCGAACGCGGCAAGT
TTTTCCGGCCATTGAAAACACAGGCTTCCGTGCGCATTGATGCCGATGTGATGGAGTGGCTAAAACGCCCAGGTAAAGGC
TATCAGACTCGCTTGAATGCGATATTGCGTGAAGCGATGTTACGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References