Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2650184..2650959 Replicon chromosome
Accession NZ_CP066792
Organism Burkholderia glumae strain FDAARGOS_921

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag I6G78_RS29565 Protein ID WP_015877380.1
Coordinates 2650462..2650959 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag I6G78_RS29560 Protein ID WP_015877381.1
Coordinates 2650184..2650465 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G78_RS29550 2649365..2649727 + 363 WP_017432434.1 hypothetical protein -
I6G78_RS29555 2649810..2650187 + 378 WP_173941242.1 hypothetical protein -
I6G78_RS29560 2650184..2650465 + 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
I6G78_RS29565 2650462..2650959 + 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
I6G78_RS29570 2651040..2651537 + 498 WP_015877379.1 ProQ activator of osmoprotectant transporter prop -
I6G78_RS29575 2651951..2652550 + 600 Protein_2201 RHS domain-containing protein -
I6G78_RS29580 2652951..2653262 + 312 WP_015877377.1 hypothetical protein -
I6G78_RS29590 2654226..2654789 + 564 Protein_2204 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T185026 WP_015877380.1 NZ_CP066792:2650462-2650959 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T185026 NZ_CP087880:1239367-1239846 [Pseudocitrobacter corydidari]
ATGGTAAAAGATCTCACGGAGAGATTAACTTATTCCCACAATGTGGATGAGTTTAGCTGCGGTGAGCCAGTGCTGGATAA
CTGGCTTCGCAGTCGGGCATTAAGTAATGAAGAGAGTGGCGCGACAAGAACATTTGTTTTATGTCCAAAAGGCAGCCAGC
AGGTAATCGGATATTACTCTTTGTCTACAGGCGCTATCCAGCGTGAAGCGGTACCCGGTGCTTTTCGTCGAAACATGCCA
GAACCTATTCCCGTTGTTTTAATTGCACGGTTCGCCGTAGATAGCGCGTTTCAAAAGCAGCGCTGGGGAGGGAAACTTCT
GCGCGAAGCGGTAATGCGTGCGATGTTAATCGCGGAAACGGTAGGCGTGCGTGGCCTCGTCGTGCATGCGCTTAATGATG
CCGCCAAGGCGTTTTATCTGCGCTTCGGTTTTGTTGTATCCCCGATCCAACCCCACACGCTGGTTCTTGCCCTTCGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT185026 WP_015877381.1 NZ_CP066792:2650184-2650465 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT185026 NZ_CP087880:1239104-1239373 [Pseudocitrobacter corydidari]
ATGACAAGCAGAAATAAAGAAGCGCCCATCAACCTTAGAGCGAATCAACGACAGCGTGATCTGATTGATCTGGCGGCACA
GCTCATCTCGCTTTCTCGCACTGATTTTATGCTTAATGCTGCCTGTGAAAAGGCACAAGAAGTGCTGTTAGATCAACGGC
TTTTTATCGTAGATGACCAGCAATTTGCCGAATTCCAACGCATCCTGGATACACCCTTGTCTGAGAACAAAGGCTTTCAG
GAACTGATGAGTGATAAATATTCATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References