Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 96732..97678 Replicon plasmid unnamed2
Accession NZ_CP066790
Organism Burkholderia glumae strain FDAARGOS_921

Toxin (Protein)


Gene name slvT Uniprot ID C5AN91
Locus tag I6G78_RS01375 Protein ID WP_012732709.1
Coordinates 97145..97678 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID C5AN90
Locus tag I6G78_RS01370 Protein ID WP_012732708.1
Coordinates 96732..97148 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G78_RS01350 92664..93743 + 1080 WP_012732706.1 ParB N-terminal domain-containing protein -
I6G78_RS01355 94080..95411 + 1332 WP_080942728.1 replication protein O -
I6G78_RS01360 95533..95859 + 327 WP_127913985.1 hypothetical protein -
I6G78_RS01365 96399..96584 + 186 WP_017432454.1 hypothetical protein -
I6G78_RS01370 96732..97148 + 417 WP_012732708.1 DUF2384 domain-containing protein Antitoxin
I6G78_RS01375 97145..97678 + 534 WP_012732709.1 RES family NAD+ phosphorylase Toxin
I6G78_RS01380 97848..98036 + 189 WP_017432455.1 hypothetical protein -
I6G78_RS01385 98788..99072 + 285 WP_017432347.1 hypothetical protein -
I6G78_RS01390 99086..99328 + 243 WP_124837682.1 hypothetical protein -
I6G78_RS01395 99325..99570 + 246 WP_127913916.1 hypothetical protein -
I6G78_RS01400 99627..99968 + 342 WP_012732710.1 hypothetical protein -
I6G78_RS01405 99971..101806 + 1836 WP_045678669.1 site-specific integrase -
I6G78_RS01410 101891..102316 + 426 WP_012734109.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144520 144520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-168)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19101.61 Da        Isoelectric Point: 4.7118

>T185024 WP_012732709.1 NZ_CP066790:97145-97678 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE

Download         Length: 534 bp

>T185024 NZ_CP087879:c2822740-2822489 [Agromyces marinus]
ATGTCGGCAATCACCGCGACCGAGGCGCGCAAGAGCCTGTTCGGCCTGATCCAGCAGGTCAACGACGATCACACCGCAGT
CGAGGTCGTCTCTCGACACGGCAACGCCGTGATCATGTCGAAGGACGACTACGACGCGATCACGGAGACCGCTCACTTGC
TGCGCAACCCTGCCAACGCCGAGCGGCTCCTCGACGCGATCGAGCGGGCGCGTCGCGGCGAGTTCGAGCAGCACGACCTC
CTCGAAGCGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14709.55 Da        Isoelectric Point: 6.4664

>AT185024 WP_012732708.1 NZ_CP066790:96732-97148 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG

Download         Length: 417 bp

>AT185024 NZ_CP087879:c2822492-2822232 [Agromyces marinus]
GTGACCCGCGCGCTCGCGTTCGATCAGAACGGCTGGGAGGACTACGTCTACTGGCAGACGCAAGACCGCAAGACGCTCAG
ACGGATCAACGTCCTGATCGCCGACGTGCTCCGTGACCCGTTCGCCGGCATCGGGAAGCCGGAGCCGCTCAAGCACATCC
TTTCGGGTGCGTGGTCTCGCCGCATCGACGAGACGAATCGGCTCGTCTACTACGTCACGGACGACCACATCGTCATCCTG
CAAGCCCGCGACCACTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9GLU3

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9GLX3

References