Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-ParD
Location 2967094..2967763 Replicon chromosome
Accession NZ_CP066784
Organism Alicyclobacillus sp. ALC3

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JC200_RS13680 Protein ID WP_274432251.1
Coordinates 2967413..2967763 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JC200_RS13675 Protein ID WP_274432250.1
Coordinates 2967094..2967408 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC200_RS13655 (JC200_13630) 2962651..2963070 + 420 WP_274432246.1 holo-ACP synthase -
JC200_RS13660 (JC200_13635) 2963121..2964584 + 1464 WP_274432247.1 NAD(P)H-hydrate dehydratase -
JC200_RS13665 (JC200_13640) 2964616..2965620 + 1005 WP_274432248.1 outer membrane lipoprotein carrier protein LolA -
JC200_RS13670 (JC200_13645) 2965813..2967069 + 1257 WP_274432249.1 alanine racemase -
JC200_RS13675 (JC200_13650) 2967094..2967408 + 315 WP_274432250.1 ribbon-helix-helix protein, CopG family Antitoxin
JC200_RS13680 (JC200_13655) 2967413..2967763 + 351 WP_274432251.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JC200_RS13685 (JC200_13660) 2967886..2969175 + 1290 WP_274432252.1 adenosylhomocysteinase -
JC200_RS13690 (JC200_13665) 2969324..2970139 + 816 WP_274432253.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
JC200_RS13695 (JC200_13670) 2970202..2970417 + 216 WP_274432254.1 DUF1659 domain-containing protein -
JC200_RS13700 (JC200_13675) 2970477..2970695 + 219 WP_274432255.1 DUF2922 domain-containing protein -
JC200_RS13705 (JC200_13680) 2970816..2971181 - 366 WP_274432256.1 DUF1450 domain-containing protein -
JC200_RS13710 (JC200_13685) 2971317..2971922 - 606 WP_274432257.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(20-57)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.10 Da        Isoelectric Point: 5.7117

>T185020 WP_274432251.1 NZ_CP066784:2967413-2967763 [Alicyclobacillus sp. ALC3]
MNVKRGDVFFADLSPVVGSEQGGFRPVLVIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEIMAEEYGLDRDSVILLEQI
RTIDKQRLTDKITHLDERMMKLVNEALQISLGLVDF

Download         Length: 351 bp

>T185020 NZ_CP087865:c1797335-1797000 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11993.78 Da        Isoelectric Point: 8.5156

>AT185020 WP_274432250.1 NZ_CP066784:2967094-2967408 [Alicyclobacillus sp. ALC3]
MSKKSDRIVVGVPHVSDSKRIVVYLPMQLVEQVDDLVERARSNRSELIREAMRQYLTEQRKFEIRNSMQQGYLEMARINL
RIASESFPLEQEAGGTVERLVSGV

Download         Length: 315 bp

>AT185020 NZ_CP087865:c1797577-1797335 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCCGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References