Detailed information of TA system TA185019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3325008..3325633
• Replicon: chromosome
• Accession: NZ_CP066777
• Organism: Morganella morganii strain FAM24091

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: CXB74_RS16270
• Protein ID: WP_024474604.1
• Coordinates: 3325430..3325633 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: CXB74_RS16265
• Protein ID: WP_046893178.1
• Coordinates: 3325008..3325367 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CXB74_RS16255 (CXB74_015975)	3320061..3321254	+	1194	WP_107678490.1	efflux RND transporter periplasmic adaptor subunit	-
CXB74_RS16260 (CXB74_015980)	3321269..3324446	+	3178	Protein_3175	efflux RND transporter permease subunit	-
CXB74_RS16265 (CXB74_015985)	3325008..3325367	+	360	WP_046893178.1	Hha toxicity modulator TomB	Antitoxin
CXB74_RS16270 (CXB74_015990)	3325430..3325633	+	204	WP_024474604.1	HHA domain-containing protein	Toxin
CXB74_RS16280 (CXB74_016000)	3326511..3327374	+	864	WP_054424719.1	acyl-CoA thioesterase II	-
CXB74_RS16285 (CXB74_016005)	3327436..3328725	-	1290	WP_107678658.1	ammonium transporter AmtB	-
CXB74_RS16290 (CXB74_016010)	3328745..3329083	-	339	WP_107678492.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T185019 WP_024474604.1 NZ_CP066777:3325430-3325633 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T185019 NZ_CP087865:1634127-1634405 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13840.57 Da
• Isoelectric Point: 4.2870

>AT185019 WP_046893178.1 NZ_CP066777:3325008-3325367 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT185019 NZ_CP087865:1634392-1634679 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2