Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 652187..652582 Replicon chromosome
Accession NZ_CP066775
Organism Mucilaginibacter ginkgonis strain HMF7856

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GO620_RS02945 Protein ID WP_157522123.1
Coordinates 652385..652582 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GO620_RS02940 Protein ID WP_198173459.1
Coordinates 652187..652384 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GO620_RS02925 649567..650466 - 900 WP_157522136.1 nucleotidyltransferase -
GO620_RS02930 650482..651597 - 1116 WP_157522132.1 M42 family metallopeptidase -
GO620_RS02935 651674..652096 - 423 WP_200230980.1 GNAT family N-acetyltransferase -
GO620_RS02940 652187..652384 + 198 WP_198173459.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GO620_RS02945 652385..652582 + 198 WP_157522123.1 type II toxin-antitoxin system HicA family toxin Toxin
GO620_RS02950 652627..653355 + 729 WP_157522120.1 DUF1211 domain-containing protein -
GO620_RS02955 653755..654750 - 996 WP_157522117.1 type I glyceraldehyde-3-phosphate dehydrogenase -
GO620_RS02960 654757..655605 - 849 WP_157522115.1 hypothetical protein -
GO620_RS02965 655610..656590 - 981 WP_157522112.1 6-phosphofructokinase -
GO620_RS02970 656720..657415 + 696 WP_157522109.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-63)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-59)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7417.65 Da        Isoelectric Point: 10.2286

>T185014 WP_157522123.1 NZ_CP066775:652385-652582 [Mucilaginibacter ginkgonis]
MPKQSYSSREIIKLLEDGGFILDQVKGSHHIYYHPVDKKRAVVPHPKKELPYGTARSILKQAGFL

Download         Length: 198 bp

>T185014 NZ_CP087865:357993-358265 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7163.91 Da        Isoelectric Point: 3.7911

>AT185014 WP_198173459.1 NZ_CP066775:652187-652384 [Mucilaginibacter ginkgonis]
MKPEPEGGFTVNVPALPGCISYGETLEEARTNAQEAIELYIESLRAHGEEIPSDENVLEYNIQLS

Download         Length: 198 bp

>AT185014 NZ_CP087865:357707-358000 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGACTAGACAACGACCTACGCCAAAAAGTCTATCCTGTGCTAGAACAATACGGCTT
GACCCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References