Detailed information of TA system TA185010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 2449979..2451729
• Replicon: chromosome
• Accession: NZ_CP066770
• Organism: Burkholderia anthina strain BJQ0011

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: JFN94_RS27425
• Protein ID: WP_124828365.1
• Coordinates: 2450833..2451729 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: JFN94_RS27420
• Protein ID: WP_124828364.1
• Coordinates: 2449979..2450836 (-)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFN94_RS27400	2445102..2446592	-	1491	WP_124828360.1	aldehyde dehydrogenase	-
JFN94_RS27405	2446690..2447529	-	840	WP_124828361.1	aspartate dehydrogenase	-
JFN94_RS27410	2447522..2449192	-	1671	WP_175796477.1	thiamine pyrophosphate-binding protein	-
JFN94_RS27415	2449185..2449982	-	798	WP_124828363.1	SDR family oxidoreductase	-
JFN94_RS27420	2449979..2450836	-	858	WP_124828364.1	IclR family transcriptional regulator	Antitoxin
JFN94_RS27425	2450833..2451729	-	897	WP_124828365.1	alpha/beta fold hydrolase	Toxin
JFN94_RS27430	2451748..2452275	-	528	WP_124828366.1	cupin domain-containing protein	-
JFN94_RS27435	2452310..2453080	-	771	WP_124828367.1	SDR family oxidoreductase	-
JFN94_RS27440	2453073..2454143	-	1071	WP_124828368.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
JFN94_RS27445	2454198..2454509	-	312	WP_124828369.1	hypothetical protein	-
JFN94_RS27450	2454511..2454828	-	318	WP_014898924.1	non-heme iron oxygenase ferredoxin subunit	-
JFN94_RS27455	2455276..2456355	+	1080	WP_124828370.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-279)

Antitoxin

• Transcription regulator IclR, N-terminal (24-72)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30815.93 Da
• Isoelectric Point: 7.4248

>T185010 WP_124828365.1 NZ_CP066770:c2451729-2450833 [Burkholderia anthina]
MSVIDKRERDRTAAFATLLGQFPEQRCEAGAAGTIGYREAGAQHAGHALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLSRAVPARIAGLLLISPAGGYGSAPAQTR
DTRRDARLAMLEELGPAGLAEQRSGNMLSGFASDEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAVAHVGLQVIPQAGHAGYVEAPAVYSSLIDGFCRQCDRQRGLE

Nucleotide

• Length: 897 bp

>T185010 NZ_CP087863:1635645-1635923 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31438.91 Da
• Isoelectric Point: 6.6561

>AT185010 WP_124828364.1 NZ_CP066770:c2450836-2449979 [Burkholderia anthina]
MSEPLQQQDAENAKSEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSLSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLTELRALYREGTLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDASLIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 858 bp

>AT185010 NZ_CP087863:1635910-1636197 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA