Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1877059..1878779 Replicon chromosome
Accession NZ_CP066770
Organism Burkholderia anthina strain BJQ0011

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JFN94_RS24635 Protein ID WP_175750584.1
Coordinates 1877059..1878387 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JFN94_RS24640 Protein ID WP_124826003.1
Coordinates 1878390..1878779 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFN94_RS24620 1872910..1874217 - 1308 WP_124826008.1 shikimate transporter -
JFN94_RS24625 1874559..1875658 + 1100 Protein_1666 VOC family protein -
JFN94_RS24630 1875715..1876950 - 1236 WP_124826005.1 NADH:flavin oxidoreductase -
JFN94_RS24635 1877059..1878387 - 1329 WP_175750584.1 type II toxin-antitoxin system HipA family toxin Toxin
JFN94_RS24640 1878390..1878779 - 390 WP_124826003.1 helix-turn-helix domain-containing protein Antitoxin
JFN94_RS24645 1878952..1880067 - 1116 WP_124826002.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
JFN94_RS24650 1880064..1881002 - 939 WP_124826001.1 alpha/beta hydrolase -
JFN94_RS24655 1881283..1882473 + 1191 WP_124826000.1 helix-turn-helix transcriptional regulator -
JFN94_RS24660 1882688..1883353 - 666 WP_124825999.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48479.20 Da        Isoelectric Point: 7.0015

>T185009 WP_175750584.1 NZ_CP066770:c1878387-1877059 [Burkholderia anthina]
MARRSRHDRLDLWMNGIPVGYWEIRHGIERLVYLPSWVDDPQGRPLSLSLPFTPGNQPHQGAVVADYFDNLLPDSQPIRR
RIAQRYRLGSTAPFELLASIGRDCVGALQLLPPDEIPVDLEAIDGTALDDAAVADVLRHATAAPLPGHPEPDGELRLSIA
GAQEKTALLRHDERWLLPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKIVAAYGLPIASCDIGRFDDQKALIVE
RFDRRLSRDGTWILRLPQEDMCQATGTPSGAKYESDGGPGIATIMGILANSADAAQDRRHFFIAQLVFWVLAAIDGHAKN
FSIAHLPGNTYRSTPLYDVLSAHPIIGTRRNQLSPHRARLAMAVCGKNRHYVIGDIQPRHWIAQGARVGLTEGDVRAAMA
DVAARTEPAIADVASRIPADFPADVADAIFDGMRRQARKLGG

Download         Length: 1329 bp

>T185009 NZ_CP087863:1164974-1165231 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13721.72 Da        Isoelectric Point: 11.8262

>AT185009 WP_124826003.1 NZ_CP066770:c1878779-1878390 [Burkholderia anthina]
MAFPVQTLSQLRPILVGFRKSAGFTQAQLAARLGVTQQSYAQLEANPSAVSIERLFKVLNVLGVRLMLEPGTPDDAPAPD
VADPAPARTPATRRRSSDTPAARSPAAASRKRPAAAAPGKPRGPKREDW

Download         Length: 390 bp

>AT185009 NZ_CP087863:1164742-1164984 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References