Detailed information of TA system TA185008

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 1870593..1871226
• Replicon: chromosome
• Accession: NZ_CP066770
• Organism: Burkholderia anthina strain BJQ0011

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JFN94_RS24610
• Protein ID: WP_124826010.1
• Coordinates: 1870813..1871226 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JFN94_RS24605
• Protein ID: WP_124826011.1
• Coordinates: 1870593..1870826 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFN94_RS24590	1865630..1867324	+	1695	WP_124826014.1	VRR-NUC domain-containing protein	-
JFN94_RS24595	1867321..1869621	+	2301	WP_199568762.1	ATP-dependent DNA helicase	-
JFN94_RS24600	1869661..1870431	-	771	WP_124826012.1	helix-turn-helix domain-containing protein	-
JFN94_RS24605	1870593..1870826	+	234	WP_124826011.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JFN94_RS24610	1870813..1871226	+	414	WP_124826010.1	PIN domain-containing protein	Toxin
JFN94_RS24615	1871397..1872698	-	1302	WP_124826009.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
JFN94_RS24620	1872910..1874217	-	1308	WP_124826008.1	shikimate transporter	-
JFN94_RS24625	1874559..1875658	+	1100	Protein_1666	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1863151..1871226	8075

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (10-119)

Antitoxin

• SpoVT-AbrB domain (5-37)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15556.84 Da
• Isoelectric Point: 5.2464

>T185008 WP_124826010.1 NZ_CP066770:1870813-1871226 [Burkholderia anthina]
MSRIESEKSFVDSNVVLYLLSEDETKANLAEALFLRRPTISVQVLNEVASVCSRKLRMPWRDVGQFLEPIRSLCRVVPIT
VDAHDLARRLAEWHRLSFYDACIVATASIEGCEYLYTEDMHDGLRVAGGPELRNPFA

Nucleotide

• Length: 414 bp

>T185008 NZ_CP087863:1164742-1164984 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8807.01 Da
• Isoelectric Point: 6.3334

>AT185008 WP_124826011.1 NZ_CP066770:1870593-1870826 [Burkholderia anthina]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLQRLRRFRGKLPADFKFSRDDANEQD

Nucleotide

• Length: 234 bp

>AT185008 NZ_CP087863:1164974-1165231 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA