Detailed information of TA system TA185007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1192880..1193500
• Replicon: chromosome
• Accession: NZ_CP066770
• Organism: Burkholderia anthina strain BJQ0011

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFN94_RS21620
• Protein ID: WP_124826598.1
• Coordinates: 1193183..1193500 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: JFN94_RS21615
• Protein ID: WP_096505596.1
• Coordinates: 1192880..1193179 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFN94_RS21600	1188781..1190400	-	1620	WP_124826543.1	OPT/YSL family transporter	-
JFN94_RS21605	1190476..1191216	-	741	WP_124826542.1	IclR family transcriptional regulator	-
JFN94_RS21610	1191545..1192831	+	1287	WP_124826541.1	DUF445 domain-containing protein	-
JFN94_RS21615	1192880..1193179	-	300	WP_096505596.1	putative addiction module antidote protein	Antitoxin
JFN94_RS21620	1193183..1193500	-	318	WP_124826598.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFN94_RS21625	1193886..1195526	+	1641	WP_124826539.1	acetolactate synthase large subunit	-
JFN94_RS21630	1195555..1196988	+	1434	WP_124826538.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (9-102)

Antitoxin

• Uncharacterized protein HI1420 (4-96)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11796.56 Da
• Isoelectric Point: 10.3009

>T185007 WP_124826598.1 NZ_CP066770:c1193500-1193183 [Burkholderia anthina]
MPYSAPTFSIRTTDVFDAWFAGLSDRVARRRIQARIDRLSMGNPGDWKSAGSPIVEMRIDHGPGYRVYYVRRATIWVILL
CGGGKSTQQADIRAAHAMLARLDLE

Nucleotide

• Length: 318 bp

>T185007 NZ_CP087863:c639020-638760 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10732.19 Da
• Isoelectric Point: 6.9777

>AT185007 WP_096505596.1 NZ_CP066770:c1193179-1192880 [Burkholderia anthina]
MDKIKTRPWDSAEHLKTDDDMAEYFDACLREAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGTKAHA

Nucleotide

• Length: 300 bp

>AT185007 NZ_CP087863:c638779-638444 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA