Detailed information of TA system TA185002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1171731..1172377
• Replicon: chromosome
• Accession: NZ_CP066763
• Organism: Burkholderia ambifaria strain BJQ0010

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JG536_RS21185
• Protein ID: WP_175667847.1
• Coordinates: 1171731..1172138 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JG536_RS21190
• Protein ID: WP_175667848.1
• Coordinates: 1172135..1172377 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG536_RS21170	1167522..1168106	-	585	WP_175667844.1	hypothetical protein	-
JG536_RS21175	1168103..1168843	-	741	WP_175667845.1	chemotaxis protein	-
JG536_RS21180	1168846..1171236	-	2391	WP_175667846.1	MCP four helix bundle domain-containing protein	-
JG536_RS21185	1171731..1172138	-	408	WP_175667847.1	type II toxin-antitoxin system VapC family toxin	Toxin
JG536_RS21190	1172135..1172377	-	243	WP_175667848.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JG536_RS21195	1172640..1173329	+	690	WP_175667849.1	phospholipase	-
JG536_RS21200	1173374..1174867	-	1494	WP_175667850.1	amino acid permease	-
JG536_RS21205	1174971..1176377	-	1407	WP_175662983.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14962.14 Da
• Isoelectric Point: 6.8823

>T185002 WP_175667847.1 NZ_CP066763:c1172138-1171731 [Burkholderia ambifaria]
MKFLLDTNAVIAILKGEQAMLARLRRHQPADFGIPAIVAHELYYGAYKSQRAAANLARVEGLQFEVVSFDAEDVQHAGEI
RAQLAAVGTPIGPYDALIAGQARARRLVLVTHNTREFERVPELQVEDWLAAAREK

Nucleotide

• Length: 408 bp

>T185002 NZ_CP087862:1909713-1909973 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8858.01 Da
• Isoelectric Point: 4.7628

>AT185002 WP_175667848.1 NZ_CP066763:c1172377-1172135 [Burkholderia ambifaria]
METAKIFKHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAAGTEPAAQERPGLDVFE

Nucleotide

• Length: 243 bp

>AT185002 NZ_CP087862:1909954-1910289 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA