Detailed information of TA system TA185001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 700574..701213
• Replicon: chromosome
• Accession: NZ_CP066763
• Organism: Burkholderia ambifaria strain BJQ0010

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JG536_RS19190
• Protein ID: WP_006753827.1
• Coordinates: 700797..701213 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q0B8R6
• Locus tag: JG536_RS19185
• Protein ID: WP_006753828.1
• Coordinates: 700574..700810 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG536_RS19170	696073..696942	+	870	WP_175667599.1	LysR family transcriptional regulator	-
JG536_RS19175	697669..698895	-	1227	WP_175667600.1	acyltransferase	-
JG536_RS19180	699122..700324	+	1203	WP_175667601.1	DUF2029 domain-containing protein	-
JG536_RS19185	700574..700810	+	237	WP_006753828.1	DNA-binding protein	Antitoxin
JG536_RS19190	700797..701213	+	417	WP_006753827.1	type II toxin-antitoxin system VapC family toxin	Toxin
JG536_RS19195	701426..701560	+	135	Protein_631	biphenyl 2,3-dioxygenase	-
JG536_RS19200	701904..702107	+	204	WP_006751843.1	cold-shock protein	-
JG536_RS19205	702569..702832	+	264	WP_006751842.1	translation initiation factor IF-1	-
JG536_RS19210	703127..703240	-	114	Protein_634	4-hydroxy-2-oxovalerate aldolase	-
JG536_RS19215	703236..703502	+	267	Protein_635	FAD-binding protein	-
JG536_RS19220	703506..704018	+	513	WP_175667602.1	transferase hexapeptide repeat family protein	-
JG536_RS19225	704295..704543	+	249	WP_012366135.1	hypothetical protein	-
JG536_RS19230	704567..705730	-	1164	WP_175667603.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	700574..709650	9076

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15295.49 Da
• Isoelectric Point: 6.9900

>T185001 WP_006753827.1 NZ_CP066763:700797-701213 [Burkholderia ambifaria]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYASNI
LPVDIETAQMWGHLRVPDPAHALDHLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T185001 NZ_CP087862:c1390696-1390454 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8682.73 Da
• Isoelectric Point: 5.0774

>AT185001 WP_006753828.1 NZ_CP066763:700574-700810 [Burkholderia ambifaria]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT185001 NZ_CP087862:c1390464-1390207 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KQ31