Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 400315..402080 Replicon chromosome
Accession NZ_CP066763
Organism Burkholderia ambifaria strain BJQ0010

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag JG536_RS17905 Protein ID WP_175667461.1
Coordinates 400315..401226 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag JG536_RS17910 Protein ID WP_105833378.1
Coordinates 401223..402080 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG536_RS17875 395680..396759 - 1080 WP_126225643.1 porin -
JG536_RS17880 397210..397527 + 318 WP_006751284.1 non-heme iron oxygenase ferredoxin subunit -
JG536_RS17885 397529..397840 + 312 WP_175667458.1 hypothetical protein -
JG536_RS17890 397895..398965 + 1071 WP_175667459.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
JG536_RS17895 398958..399728 + 771 WP_175667460.1 SDR family oxidoreductase -
JG536_RS17900 399768..400295 + 528 WP_006751280.1 cupin domain-containing protein -
JG536_RS17905 400315..401226 + 912 WP_175667461.1 alpha/beta fold hydrolase Toxin
JG536_RS17910 401223..402080 + 858 WP_105833378.1 IclR family transcriptional regulator Antitoxin
JG536_RS17915 402077..402874 + 798 WP_175667462.1 SDR family oxidoreductase -
JG536_RS17920 402867..404534 + 1668 WP_175654558.1 thiamine pyrophosphate-binding protein -
JG536_RS17925 404527..405354 + 828 WP_175663581.1 aspartate dehydrogenase -
JG536_RS17930 405453..406943 + 1491 WP_175667463.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, C-terminal

(144-266)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31276.56 Da        Isoelectric Point: 6.8171

>T185000 WP_175667461.1 NZ_CP066763:400315-401226 [Burkholderia ambifaria]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHGASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PAETRDTRRDARLAMLDELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLVNADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA

Download         Length: 912 bp

>T185000 NZ_CP087862:c1390464-1390207 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31385.91 Da        Isoelectric Point: 6.3573

>AT185000 WP_105833378.1 NZ_CP066763:401223-402080 [Burkholderia ambifaria]
MSEPLQQPESDSTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEVIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT185000 NZ_CP087862:c1390696-1390454 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References