Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 308763..309418 Replicon chromosome
Accession NZ_CP066763
Organism Burkholderia ambifaria strain BJQ0010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JG536_RS17440 Protein ID WP_175667396.1
Coordinates 308999..309418 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JG536_RS17435 Protein ID WP_175668363.1
Coordinates 308763..309002 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG536_RS17410 304028..304423 - 396 WP_006759143.1 type II toxin-antitoxin system VapC family toxin -
JG536_RS17415 304420..304659 - 240 WP_175667392.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JG536_RS17420 304759..305442 - 684 WP_175667393.1 Fe2+-dependent dioxygenase -
JG536_RS17425 305439..306194 - 756 WP_175667394.1 sel1 repeat family protein -
JG536_RS17430 306198..308441 - 2244 WP_175667395.1 TonB-dependent siderophore receptor -
JG536_RS17435 308763..309002 + 240 WP_175668363.1 Arc family DNA-binding protein Antitoxin
JG536_RS17440 308999..309418 + 420 WP_175667396.1 type II toxin-antitoxin system VapC family toxin Toxin
JG536_RS17445 309561..310856 - 1296 WP_175667397.1 aspartate carbamoyltransferase -
JG536_RS17450 311092..311226 + 135 WP_175667398.1 entericidin A/B family lipoprotein -
JG536_RS17455 311326..311898 - 573 WP_175667399.1 permease -
JG536_RS17460 312024..312983 - 960 WP_175667400.1 DMT family transporter -
JG536_RS17465 313372..314166 - 795 WP_175667401.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14966.23 Da        Isoelectric Point: 6.4738

>T184999 WP_175667396.1 NZ_CP066763:308999-309418 [Burkholderia ambifaria]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGKRRDWLHHSIEQRVVPLFRGRILPFDD
AASKAYASLRAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAVGLRVIDPWAG

Download         Length: 420 bp

>T184999 NZ_CP087862:c921362-921084 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8615.80 Da        Isoelectric Point: 5.7084

>AT184999 WP_175668363.1 NZ_CP066763:308763-309002 [Burkholderia ambifaria]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRAILEEAVRPGGRAKLGTLLAEIGREAGGVDFEIPRESAPTDPMSFE

Download         Length: 240 bp

>AT184999 NZ_CP087862:c921097-920810 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References