Detailed information of TA system TA184998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 250018..250541
• Replicon: chromosome
• Accession: NZ_CP066763
• Organism: Burkholderia ambifaria strain BJQ0010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B1YYI4
• Locus tag: JG536_RS17170
• Protein ID: WP_012366508.1
• Coordinates: 250018..250284 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JG536_RS17175
• Protein ID: WP_175667365.1
• Coordinates: 250281..250541 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG536_RS17145	245198..246451	-	1254	WP_175667361.1	diaminopimelate decarboxylase	-
JG536_RS17150	246561..247475	+	915	WP_175667362.1	LysR family transcriptional regulator	-
JG536_RS17155	247563..248162	+	600	WP_175667363.1	GNAT family N-acetyltransferase	-
JG536_RS17160	248291..248863	-	573	WP_011659229.1	DUF4142 domain-containing protein	-
JG536_RS17165	249276..249899	-	624	WP_175667364.1	HAD hydrolase-like protein	-
JG536_RS17170	250018..250284	-	267	WP_012366508.1	Txe/YoeB family addiction module toxin	Toxin
JG536_RS17175	250281..250541	-	261	WP_175667365.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JG536_RS17180	250694..251137	+	444	WP_175667366.1	GNAT family N-acetyltransferase	-
JG536_RS17185	251193..251411	+	219	WP_006751720.1	DUF1653 domain-containing protein	-
JG536_RS17190	251518..252729	-	1212	WP_175667367.1	winged helix DNA-binding domain-containing protein	-
JG536_RS17195	253078..254466	-	1389	WP_105830399.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10468.82 Da
• Isoelectric Point: 8.8834

>T184998 WP_012366508.1 NZ_CP066763:c250284-250018 [Burkholderia ambifaria]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYHYA

Nucleotide

• Length: 267 bp

>T184998 NZ_CP087862:758653-758988 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9700.99 Da
• Isoelectric Point: 6.4820

>AT184998 WP_175667365.1 NZ_CP066763:c250541-250281 [Burkholderia ambifaria]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQEYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEGDE

Nucleotide

• Length: 261 bp

>AT184998 NZ_CP087862:758411-758653 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCCGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Structures

Toxin

• AlphaFold DB: A0A102EVD7