Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 91531..92778 Replicon chromosome
Accession NZ_CP066763
Organism Burkholderia ambifaria strain BJQ0010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JG536_RS16460 Protein ID WP_175667267.1
Coordinates 91531..92112 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JG536_RS16465 Protein ID WP_175667268.1
Coordinates 92221..92778 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG536_RS16440 86659..87837 - 1179 WP_175667263.1 macrolide transporter subunit MacA -
JG536_RS16445 88210..88935 - 726 WP_175667264.1 DsbC family protein -
JG536_RS16450 88974..89714 - 741 WP_175667265.1 hypothetical protein -
JG536_RS16455 90745..91473 - 729 WP_175667266.1 class I SAM-dependent methyltransferase -
JG536_RS16460 91531..92112 - 582 WP_175667267.1 HD domain-containing protein Toxin
JG536_RS16465 92221..92778 - 558 WP_175667268.1 helix-turn-helix domain-containing protein Antitoxin
JG536_RS16470 92850..93497 - 648 WP_175667269.1 hypothetical protein -
JG536_RS16475 93860..95263 + 1404 WP_175667270.1 DUF308 domain-containing protein -
JG536_RS16480 95445..96176 + 732 WP_175667271.1 ribonuclease T2 -
JG536_RS16485 96259..96894 - 636 WP_175667272.1 cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-161)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21514.02 Da        Isoelectric Point: 4.7641

>T184997 WP_175667267.1 NZ_CP066763:c92112-91531 [Burkholderia ambifaria]
MNLDTIHARLDFLREAERLKDVLRSGHTSTGRRESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRALRDEIVALWDEYEAAESPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDATPLFDAIRAIVDADTQRRIDARGDGA

Download         Length: 582 bp

>T184997 NZ_CP087862:639732-640133 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTGCATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCATACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20240.23 Da        Isoelectric Point: 11.0874

>AT184997 WP_175667268.1 NZ_CP066763:c92778-92221 [Burkholderia ambifaria]
MTTSPLHTPPLGPQLKRWRTLRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPARAAEFSRPLPALLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGTNASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT184997 NZ_CP087862:639484-639717 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References