Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1712485..1713170 Replicon chromosome
Accession NZ_CP066762
Organism Burkholderia ambifaria strain BJQ0010

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JG536_RS07975 Protein ID WP_175669075.1
Coordinates 1712748..1713170 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JG536_RS07970 Protein ID WP_175669076.1
Coordinates 1712485..1712751 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG536_RS07955 1707977..1710265 + 2289 WP_175669078.1 TonB-dependent siderophore receptor -
JG536_RS07960 1710352..1711191 + 840 WP_006755049.1 folate-dependent phosphoribosylglycinamide formyltransferase PurN-like protein -
JG536_RS07965 1711191..1712207 + 1017 WP_175669077.1 acetyltransferase -
JG536_RS07970 1712485..1712751 + 267 WP_175669076.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JG536_RS07975 1712748..1713170 + 423 WP_175669075.1 type II toxin-antitoxin system VapC family toxin Toxin
JG536_RS07980 1713251..1713691 - 441 WP_105834506.1 MaoC family dehydratase -
JG536_RS07985 1713963..1714868 - 906 WP_175669074.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
JG536_RS07990 1714837..1715907 - 1071 WP_175669073.1 hypothetical protein -
JG536_RS07995 1716265..1717428 + 1164 WP_175669072.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14758.86 Da        Isoelectric Point: 7.8895

>T184996 WP_175669075.1 NZ_CP066762:1712748-1713170 [Burkholderia ambifaria]
VTTLYMLDTNICSFIMRERPAAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATTAIRVDLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA

Download         Length: 423 bp

>T184996 NZ_CP087862:c590244-589909 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10014.33 Da        Isoelectric Point: 4.5498

>AT184996 WP_175669076.1 NZ_CP066762:1712485-1712751 [Burkholderia ambifaria]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFATEPRADADFLVERPTVVEAGRFELPGADD
DVPTESAR

Download         Length: 267 bp

>AT184996 NZ_CP087862:c589919-589638 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References