Detailed information of TA system TA184995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 152316..152953
• Replicon: chromosome
• Accession: NZ_CP066762
• Organism: Burkholderia ambifaria strain BJQ0010

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JG536_RS00660
• Protein ID: WP_175669807.1
• Coordinates: 152552..152953 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: JG536_RS00655
• Protein ID: WP_105831335.1
• Coordinates: 152316..152552 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG536_RS00635	148318..149421	-	1104	WP_175669803.1	ADP-heptose--LPS heptosyltransferase	-
JG536_RS00640	149418..151121	-	1704	WP_175669804.1	thiamine pyrophosphate-binding protein	-
JG536_RS00645	151400..151861	+	462	WP_175669805.1	hypothetical protein	-
JG536_RS00650	151858..152142	+	285	WP_175669806.1	type II toxin-antitoxin system RelE/ParE family toxin	-
JG536_RS00655	152316..152552	+	237	WP_105831335.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JG536_RS00660	152552..152953	+	402	WP_175669807.1	type II toxin-antitoxin system VapC family toxin	Toxin
JG536_RS00665	153021..154409	-	1389	WP_105831292.1	L-serine ammonia-lyase	-
JG536_RS00670	154440..155576	-	1137	WP_175669808.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15065.22 Da
• Isoelectric Point: 4.9203

>T184995 WP_175669807.1 NZ_CP066762:152552-152953 [Burkholderia ambifaria]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Nucleotide

• Length: 402 bp

>T184995 NZ_CP087862:188869-189171 [Moraxella bovis]
ATGACCAAGTCTGATAAATTAAAAGCCAAATTGTATGGCGATGTACGAACTTTTGTATTTAGTGATTTGGTTACTTTATT
ATCGCAATTAGGTTATGAAATGCACGAACGGGCAGGTTCTCGTGTGGTATTTGTTCATTGTGATGATAATAGCGACCGCA
TTCATTTGCATAAACCCCACCCCGAAAATACCATTAAAGGTGGAGCATTAAAAGCGGTCAAAGCCTATTTGTCCGAAAAA
GGCTATTTTGATGAATTTAATGATGATGTGTTAAATCAGGAGCTTAAAAATGATGACCTATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9029.15 Da
• Isoelectric Point: 5.8770

>AT184995 WP_105831335.1 NZ_CP066762:152316-152552 [Burkholderia ambifaria]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPTRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREGL

Nucleotide

• Length: 237 bp

>AT184995 NZ_CP087862:189158-189493 [Moraxella bovis]
ATGATGACCTATAAAGGCTATGTTGGCGAATTTACGCTTGATAATGATGATGAAATATTTTATGGTAAACTTATTGGCAT
TAATCAGCTTGTTACTTTTGAAGCAGACAATGCCCATGATTTAAAACAAGCCTTTTATGACAGCGTGGACGATTATTTGG
CGTTTTGTGCTGAACAAGGCATAGAGCCTGATAAGCCTTTTAAGGGTTCATTTAATGTGCGTATTGATAGCGAATTGCAC
CGCCGTGCTTATATGGCAAGCCGTGACAGTAGTTTAAATGCGTTTGTAGGACAAGCCATTAGTGAAAAGCTAAATAGAAT
GGCTGTATCAATATAA